Evidence map›Paper›PMID 38134240›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2024

Changes in Adiposity and Cognitive Function in Older Adults: The REGARDS Study.

Wenfei Zhu, Yanbing Li, Chenxi Zhao, Virginia J Howard, Virginia G Wadley, Suzanne E Judd, Natalie Colabianchi, Leslie A McClure, Steven P Hooker, Yuliang Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenfei ZhuSchool of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.
Yanbing LiSchool of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.ORCID 0009-0002-7993-4692
Chenxi ZhaoSchool of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.
Virginia J HowardDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Virginia G WadleyDepartment of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Suzanne E JuddDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Natalie ColabianchiSchool of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.
Leslie A McClureCollege for Public Health and Social Justice, Saint Louis University, Saint Louis, Missouri, USA.
Steven P HookerCollege of Health and Human Services, San Diego State University, San Diego, California, USA.
Yuliang SunSchool of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Impact of Physical Activity on Stroke and Cognitive Function in Older AdultsR01NS061846 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HOOKER, STEVEN PAUL · 2008 to 2012
$2.9M
NIA NIH HHSNIH HHSNINDS NIH HHSNINDS NIH HHS R01 NS061846NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

objectivesAdiposity may have a role in the risk of dementia. Fewer studies have focused on the relationship between change in adiposity and cognitive decline. Our study aimed to explore the association between the change in adiposity and cognitive function in Black and White older adults.

methodsThe participants were 12,204 older adults without cognitive impairment (62.8 ± 8.0 years) in the United States. The percent body mass index change (%BMI change) and percent waist circumference change (%WC change) were measured at 2 in-home visits (first: 2003-2007, second: 2013-2016). Cognitive status was assessed by the Six-Item Screener annually. Memory and executive function were measured by word list learning, MOCA recall and orientation, and letter and animal fluency every 2 years. Logistic regression or linear regression models were used to estimate the relationship between percent change in adiposity and cognitive function.

resultsAfter 12.7 ± 1.7 years, a greater decrease in %BMI change or %WC change was significantly associated with a higher risk of cognitive impairment. Compared to older adults with -5% ≤ change ≤ 5% from baseline, a significantly higher risk of cognitive impairment and greater loss in memory and executive function were found among those who experienced more than a 10% decline in %BMI change or %WC change. Older adults who experienced a 5%-10% decrease in %BMI change had a higher risk of cognitive impairment and greater loss of memory compared to those with -5% ≤ change ≤ 5%. DISCUSSION: A greater decrease in %BMI (>5%) and %WC (>10%) change was associated with greater cognitive loss observed over time.

Indexed as

Cognition DisordersCognitive DysfunctionAdiposityAgedBody Mass IndexCognitionHumansObesityRisk FactorsUnited StatesAdiposityExecutive functionMemoryMild cognitive impairment

Identifiers

PMID38134240
PMCPMC10873843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.