ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2024
Macular choroidal thickness, volume, and vascularity index in patients with systemic sclerosis.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ocular markers of microangiopathy and their possible association with cardiovascular risk in patients with systemic inflammatory rheumatic diseases: a systematic review.Frontiers in immunology · 2025Pooled it
- Microvascular markers in systemic sclerosis: a comparative OCT-angiography and nailfold videocapillaroscopy study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Editorial: Imaging in the diagnosis and treatment of eye diseases.Frontiers in ophthalmology · 2026Article
- Interocular symmetry of retinal and choroidal OCT parameters in precapillary pulmonary hypertension: a brief research report.Frontiers in medicine · 2026Article
- The choroid as a vascular sensor in pulmonary hypertension: an oculomic mini review.Frontiers in cardiovascular medicine · 2026Review
- Anterior segment oculomics in systemic sclerosis: reduced OCT-derived pupil diameter without iris morphology alterations.Frontiers in medicine · 2026Article
- Retinal Assessment and the Retina-Choroid Link in Precapillary Pulmonary Hypertension: A Single-Center Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Evaluation of choroidal vascularity index and choroidal thickness in patients with primary Sjögren's syndrome.International ophthalmology · 2025Article
- Linking cardiological parameters and choroidal changes in patients with precapillary pulmonary hypertension: a cross-sectional study.Scientific reports · 2025Article
- Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults.Journal of the American Heart Association · 2025Article
- Assessment of interocular symmetry of choroidal vascularity index and thickness in patients with systemic sclerosis: a prospective study.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeThe aim of this study was to investigate choroidal parameters in patients with systemic sclerosis (SSc) using enhanced depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT) and to determine their relationships with clinical variables and ocular features.
methodsThirty-three patients with SSc and 40 controls were enrolled. The groups did not differ with regard to age, sex, and axial length. The mean choroidal thickness and volume were obtained in each conventional Early Treatment of Diabetic Retinopathy Study grid subfield. The choroidal vascularity index (CVI), which provides a quantitative analysis of vasculature by calculating the proportion of the luminal area (LA) to the total choroidal area (TCA), was determined.
resultsLower choroidal thickness and volume were observed in the SSc group. The CVI was significantly higher in SSc patients, whereas the TCA, LA, and stromal area were significantly lower in the SSc group; however, the significant difference of the stromal component was more pronounced than that of the luminal component. Regression analyses did not identify any clinical factors associated with the CVI (except Ca-blocker use), central macular thickness, or volume. No significant differences in choroidal parameters were found within the SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) vs. limited cutaneous systemic sclerosis (lcSSc)), or between eyes stratified according to SSc pattern (early, active, or late) using nailfold capillaroscopy (p > 0.05 for all).
conclusionOur results, with notably higher CVI values, may shed new light on choroidal impairment in patients with SSc. Stromal involvement appeared to dominate the vascular component.
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