ArticleClinical rheumatology2024
Understanding muscle coordination during gait based on muscle synergy and its association with symptoms in patients with knee osteoarthritis.
Article in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Radiographic Knee Osteoarthritis Identification Using Wearable Plantar Pressure: Secondary Cross-Sectional Analysis of Interpretable Framework Integrating Biomechanical Descriptors and the Multiscale Synergy Index.JMIR mHealth and uHealth · 2026Article
- Severity-Dependent Contributions of Knee Adduction Moment Lever Arm Components and Associated Gait Variables in Medial Knee Osteoarthritis.Annals of biomedical engineering · 2026Article
- Muscle Synergy During Cutting Movements in Athletes with a History of Groin Pain.Sports (Basel, Switzerland) · 2025Article
- Correlation analysis between the mDIXON-quant fat quantification parameters of the infrapatellar fat pad and the severity of knee osteoarthritis.Journal of orthopaedic surgery and research · 2025Article
- Characterization of Muscle Activation and Muscle Synergism in the 'Forward Lunge' Gait Movement of Badminton Players Using Surface Electromyography Sensors.Sensors (Basel, Switzerland) · 2025Article
- Factors, characteristics and influences of the changes of muscle activation patterns for patients with knee osteoarthritis: a review.Journal of orthopaedic surgery and research · 2025Review
- Correlation between quadriceps activation and proprioception in patients with knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- Changes in walking function and neural control following pelvic cancer surgery with reconstruction.Frontiers in bioengineering and biotechnology · 2024Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe aimed to investigate the muscle coordination differences between a control group and patients with mild and severe knee osteoarthritis (KOA) using muscle synergy analysis and determine whether muscle coordination was associated with symptoms of KOA.
methodFifty-three women with medial KOA and 19 control patients participated in the study. The gait analyses and muscle activity measurements of seven lower limb muscles were assessed using a motion capture system and electromyography. Gait speed and knee adduction moment impulse were calculated. The spatiotemporal components of muscle synergy were extracted using non-negative matrix factorization, and the dynamic motor control index during walking (walk-DMC) was computed. The number of muscle synergy and their spatiotemporal components were compared among the mild KOA, severe KOA, and control groups. Moreover, the association between KOA symptoms with walk-DMC and other gait parameters was evaluated using multi-linear regression analysis.
resultsThe number of muscle synergies was lower in mild and severe KOA compared with those in the control group. In synergy 1, the weightings of biceps femoris and gluteus medius in severe KOA were higher than that in the control group. In synergy 3, the weightings of higher tibial anterior and lower gastrocnemius lateralis were confirmed in the mild KOA group. Regression analysis showed that the walk-DMC was independently associated with knee-related symptoms of KOA after adjusting for the covariates.
conclusionsMuscle coordination was altered in patients with KOA. The correlation between muscle coordination and KOA may be attributed to the knee-related symptoms. Key points • Patients with knee osteoarthritis (OA) experienced a deterioration in muscle coordination when walking. • Loss of muscle coordination was associated with severe knee-related symptoms in knee OA. • Considering muscle coordination as a knee OA symptom-related factor may provide improved treatment.
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