Bridging the Camera Domain Gap With Image-to-Image Translation Improves Glaucoma Diagnosis.

Purpose: The purpose of this study was to improve the automated diagnosis of glaucomatous optic neuropathy (GON), we propose a generative adversarial network (GAN) model that translates Optain images to Topcon images. Methods: We trained the GAN model on 725 paired images from Topcon and Optain cameras and externally validated it using an additional 843 paired images collected from the Aravind Eye Hospital in India. An optic disc segmentation model was used to assess the disparities in disc parameters across cameras. The performance of the translated images was evaluated using root mean square error (RMSE), peak signal-to-noise ratio (PSNR), structural similarity index (SSIM), 95% limits of agreement (LOA), Pearson's correlations, and Cohen's Kappa coefficient. The evaluation compared the performance of the GON model on Topcon photographs as a reference to that of Optain photographs and GAN-translated photographs. Results: The GAN model significantly reduced Optain false positive results for GON diagnosis, with RMSE, PSNR, and SSIM of GAN images being 0.067, 14.31, and 0.64, respectively, the mean difference of VCDR and cup-to-disc area ratio between Topcon and GAN images being 0.03, 95% LOA ranging from -0.09 to 0.15 and -0.05 to 0.10. Pearson correlation coefficients increased from 0.61 to 0.85 in VCDR and 0.70 to 0.89 in cup-to-disc area ratio, whereas Cohen's Kappa improved from 0.32 to 0.60 after GAN translation. Conclusions: Image-to-image translation across cameras can be achieved by using GAN to solve the problem of disc overexposure in Optain cameras. Translational Relevance: Our approach enhances the generalizability of deep learning diagnostic models, ensuring their performance on cameras that are outside of the original training data set.