Evidence map›Paper›PMID 38133151›Full record

ArticleArtificial organs2024

Increased phagocytosis capacity of circulating neutrophils in patients on continuous flow ventricular assist device support.

Morcos A Awad, Wenji Sun, Dong Han, Bartley P Griffith, Zhongjun J Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Morcos A AwadDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-2568-3330
Wenji SunDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Dong HanDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Bartley P GriffithDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Zhongjun J WuDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-0807-7195
University of Maryland, Baltimore · US

Funding

First-in-Human Use of an Artificial Lung for Ambulatory Respiratory SupportR01HL118372 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P, WU, ZHONGJUN JON · 2013 to 2023
$7.9M
Computational Modeling of Device-Induced Platelet Activation and Receptor Shedding Relevant to Thrombosis and Bleeding in Device-Assisted CirculationR01HL162940 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Zhongjun Jon Wu · 2023 to 2026
$2.0M
Shear-Induced Hemostatic Dysfunction and Bleeding in CF-VAD PatientsR01HL124170 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P, WU, ZHONGJUN JON · 2015 to 2018
$2.0M
High Mechanical Shear Stress-Induced Neutrophil Dysfunction in Mechanically Assisted CirculationR01HL171120 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Zhongjun Jon Wu · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL118372NHLBI NIH HHS R01 HL124170NHLBI NIH HHS R01 HL162940NHLBI NIH HHS R01 HL171120NIH HHS
6 · The paper itself

Abstract

backgroundNeutrophils take part in the innate immune response, phagocytosis, and pro-inflammatory cytokine release. The phagocytic capacity of circulating neutrophils in patients on continuous flow (CF) ventricular assist device (VAD) has not been well studied.

methodsBlood samples from 14 patients undergoing CF-VAD implantation were collected and analyzed preoperatively (at baseline) and on postoperative days (POD) 3, 7, 14, and 28. Flow cytometry was used to assess the surface expression levels of CD62L, CD162, and macrophage antigen-1 (MAC-1) and neutrophil phagocytic capacity. Interleukin 1 (IL1), IL6, IL8, TNF-α, neutrophil elastase, and myeloperoxidase in plasma were measured using enzyme-linked immunosorbent assays.

resultsAmong the 14 patients, seven patients had preoperative bridge device support. Relative to baseline, patients with no bridge device had elevated leukocyte count and neutrophil elastase by POD3 which normalized by POD7. Neutrophil activation level, IL6, IL8, and TNF-α increased by POD3 and sustained elevated levels for 7-14 days postoperatively. Elevated neutrophil phagocytic capacity persisted even until POD28. Similar patterns were observed in patients on a preoperative bridge device.

conclusionsNeutrophil activation and phagocytic capacity increased in response to VAD support, while inflammatory cytokines remain elevated for up to 2 weeks postoperatively. These findings may indicate that VAD implantation elicits circulating neutrophils to an abnormal preemptive phagocytotic phenotype.

Indexed as

CytokinesHeart-Assist DevicesNeutrophilsPhagocytosisAdultAgedFemaleHeart FailureHumansMaleMiddle AgedNeutrophil ActivationCytokinescontinuous flow ventricular assist deviceinflammatory cytokinesneutrophilsphagocytosis

Identifiers

PMID38133151
PMCPMC11105991
OpenAlexW4390114392

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.