Evidence map›Paper›PMID 38133080›Full record

Trial reportHead & neck2024

Tongue electrical impedance myography correlates with functional, neurophysiologic, and clinical outcome measures in long-term oropharyngeal cancer survivors with and without hypoglossal neuropathy: An exploratory study.

Nathan J Hansen, Karin Woodman, Sheila Buoy, Shitong Mao, Carly E A Barbon, Stephen Y Lai, C David Fuller, Katherine A Hutcheson, Benjamin Sanchez

2 registry-linked trialsOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Head & neck, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04151082 phase1 / phase2recruitingnot on this map

Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial and Data Registry

TypeinterventionalSponsorM.D. Anderson Cancer CenterRan2019 to 2027Enrolled35ConditionsCranial Nerve Disorder, Head and Neck Carcinoma, Oropharyngeal CarcinomaArmsMethylprednisolone, Prednisone, Quality-of-Life Assessment, Questionnaire Administration
NCT07570056 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Study for the Use of Electrical Bioimpedance in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Patients (Bioimpedance)

TypeobservationalSponsorUniversity of UtahRan2026 to 2027Enrolled25ConditionsMyelodysplastic Syndromes, Acute Myeloid LeukemiaArmsBioimpedance (BioZ)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nathan J HansenDepartment of Electrical and Computer Engineering, The University of Utah, Salt Lake City, Utah, USA.
Karin WoodmanDepartment of Neurology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-5972-0278
Sheila BuoyDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.
Shitong MaoDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-5122-7497
Carly E A BarbonDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.
Stephen Y LaiDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.
C David FullerDivision of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-5264-3994
Katherine A HutchesonDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-3710-5706
Benjamin SanchezDepartment of Electrical and Computer Engineering, The University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-1594-9847
The University of Texas MD Anderson Cancer Center · USUniversity of Utah · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Dissemination and implementation of DIGEST™ as an evidence-based measurement tool for dysphagia in cancerR01CA271223 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Katherine Arnold Hutcheson · 2023 to 2026
$2.6M
Hypoglossal neuropathy in the pathogenesis of radiation associated dysphagia (hRAD)R21CA273984 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HUTCHESON, KATHERINE ARNOLD, SANCHEZ TERRONES, BENJAMIN · 2023 to 2024
$387k
NCI NIH HHS P30 CA042014NCI NIH HHS P30CA042014NCI NIH HHS R01 CA271223NCI NIH HHS R21 CA273984NCI NIH HHS R21CA273984-01Patient-Centered Outcomes Research Institute
6 · The paper itself

Abstract

backgroundThis pilot study analyzed correlations between tongue electrical impedance myography (EIM), standard tongue electromyography (EMG), and tongue functional measures in N = 4 long-term oropharyngeal cancer (OPC) survivors.

methodsPatients were screened for a supportive care trial (NCT04151082). Hypoglossal nerve function was evaluated with genioglossus needle EMG, functional measures with the Iowa oral performance instrument (IOPI), and multi-frequency tissue composition with tongue EIM.

resultsTongue EIM conductivity was higher for patients with EMG-confirmed cranial nerve XII neuropathy than those without (p = 0.005) and in patients with mild versus normal EMG reinnervation ratings (16 kHz EIM: p = 0.051). Tongue EIM correlated with IOPI strength measurements (e.g., anterior maximum isometric lingual strength: r

conclusionsTongue EIM measures related to tongue strength and the presence of XII neuropathy. Noninvasive tongue EIM may be a convenient adjunctive biomarker to assess tongue health in OPC survivors.

Indexed as

Hypoglossal Nerve DiseasesOropharyngeal NeoplasmsElectric ImpedanceHumansMuscle, SkeletalMyographyOutcome Assessment, Health CarePilot ProjectsSurvivorsTongueelectrical impedance myographyhead and neck cancerlower cranial neuropathyradiotherapy

Identifiers

PMID38133080
PMCPMC10922903
OpenAlexW4390114439

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.