Evidence map›Paper›PMID 38133069›Full record

ArticleTomography (Ann Arbor, Mich.)2023

Artificial Intelligence for Image-Based Breast Cancer Risk Prediction Using Attention.

Stepan Romanov, Sacha Howell, Elaine Harkness, Megan Bydder, D Gareth Evans, Steven Squires, Martin Fergie, Sue Astley

Abstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Bridging the Gap: Scenario Planning for Science and Technology in Breast Cancer.Medical journal of the Islamic Republic of Iran · 2025
    Article
  5. Review
  6. Review
  7. New Frontiers in Breast Cancer Imaging: The Rise of AI.Bioengineering (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stepan RomanovDivision of Informatics, Imaging and Data Science, University of Manchester, Manchester M13 9PT, UK.ORCID 0000-0002-5395-0427
Sacha HowellDivision of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.ORCID 0000-0001-8141-6515
Elaine HarknessDivision of Informatics, Imaging and Data Science, University of Manchester, Manchester M13 9PT, UK.ORCID 0000-0001-6625-7739
Megan BydderThe Nightingale Centre, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.
D Gareth EvansThe Nightingale Centre, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.ORCID 0000-0002-8482-5784
Steven SquiresDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter EX4 4PY, UK.
Martin FergieDivision of Informatics, Imaging and Data Science, University of Manchester, Manchester M13 9PT, UK.ORCID 0000-0002-9531-6109
Sue AstleyDivision of Informatics, Imaging and Data Science, University of Manchester, Manchester M13 9PT, UK.

Funding

Medical Research Council MR/N013751/1
6 · The paper itself

Abstract

Accurate prediction of individual breast cancer risk paves the way for personalised prevention and early detection. The incorporation of genetic information and breast density has been shown to improve predictions for existing models, but detailed image-based features are yet to be included despite correlating with risk. Complex information can be extracted from mammograms using deep-learning algorithms, however, this is a challenging area of research, partly due to the lack of data within the field, and partly due to the computational burden. We propose an attention-based Multiple Instance Learning (MIL) model that can make accurate, short-term risk predictions from mammograms taken prior to the detection of cancer at full resolution. Current screen-detected cancers are mixed in with priors during model development to promote the detection of features associated with risk specifically and features associated with cancer formation, in addition to alleviating data scarcity issues. MAI-risk achieves an AUC of 0.747 [0.711, 0.783] in cancer-free screening mammograms of women who went on to develop a screen-detected or interval cancer between 5 and 55 months, outperforming both IBIS (AUC 0.594 [0.557, 0.633]) and VAS (AUC 0.649 [0.614, 0.683]) alone when accounting for established clinical risk factors.

Indexed as

Breast NeoplasmsAlgorithmsArtificial IntelligenceBreastFemaleHumansMammographyattentiondeep learningmammographymultiple instance learningrisk prediction

Identifiers

PMID38133069
PMCPMC10747439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.