Evidence map›Paper›PMID 38132964›Full record

ReviewMarine drugs2023

Dietary Astaxanthin: A Promising Antioxidant and Anti-Inflammatory Agent for Brain Aging and Adult Neurogenesis.

Alessandro Medoro, Sergio Davinelli, Luigi Milella, Bradley J Willcox, Richard C Allsopp, Giovanni Scapagnini, Donald Craig Willcox

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. The Role of Phytochemicals in Aging and Aging-Related Diseases.Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Neuroprotective Potential ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Alessandro MedoroDepartment of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.ORCID 0000-0002-6285-607X
Sergio DavinelliDepartment of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.ORCID 0000-0003-2578-7199
Luigi MilellaDepartment of Science, University of Basilicata, V. le Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-5874-1237
Bradley J WillcoxCenter of Biomedical Research Excellence for Translational Research on Aging, Kuakini Medical Center, Honolulu, HI 96817, USA.
Richard C AllsoppCenter of Biomedical Research Excellence for Translational Research on Aging, Kuakini Medical Center, Honolulu, HI 96817, USA.
Giovanni ScapagniniDepartment of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.ORCID 0000-0003-1592-5586
Donald Craig WillcoxCenter of Biomedical Research Excellence for Translational Research on Aging, Kuakini Medical Center, Honolulu, HI 96817, USA.
University of Molise · ITUniversity of Hawaiʻi at Mānoa · USBiogen (United States) · USUniversity of Basilicata · IT

Funding

FOXO3 Genotype, InflammAging, Cardiovascular Disease, and Dementia. Kuakini Hawaii Lifespan Study III. Administrative Supplement.R01AG027060 · NIA · KUAKINI MEDICAL CENTER · PI Gregory J. Tranah, BRADLEY JOHN WILLCOX · 2005 to 2026
$8.1M
NIA NIH HHS R01 AG027060
6 · The paper itself

Abstract

Decreased adult neurogenesis, or the gradual depletion of neural stem cells in adult neurogenic niches, is considered a hallmark of brain aging. This review provides a comprehensive overview of the intricate relationship between aging, adult neurogenesis, and the potential neuroregenerative properties of astaxanthin, a carotenoid principally extracted from the microalga

Indexed as

AntioxidantsNeural Stem CellsAnti-Inflammatory AgentsBrainHumansNeurogenesisNeuroinflammatory DiseasesXanthophyllsAnti-Inflammatory AgentsAntioxidantsastaxanthineXanthophyllsadult neurogenesisagingastaxanthinbrainFOXO3NF-κBNrf2

Identifiers

PMID38132964
PMCPMC10744637
OpenAlexW4389892107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.