Evidence map›Paper›PMID 38132960›Full record

ArticleMarine drugs2023

Novel BRICHOS-Related Antimicrobial Peptides from the Marine Worm

Pavel V Panteleev, Victoria N Safronova, Shuting Duan, Alexey S Komlev, Ilia A Bolosov, Roman N Kruglikov, Tatiana I Kombarova, Olga V Korobova, Eugenia S Pereskokova, Alexander I Borzilov and 5 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Pavel V PanteleevM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0001-8448-031X
Victoria N SafronovaM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Shuting DuanM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Alexey S KomlevInstitute of Experimental Medicine, WCRC "Center for Personalized Medicine", 197022 St. Petersburg, Russia.
Ilia A BolosovM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-3539-4906
Roman N KruglikovM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Tatiana I KombarovaState Research Center for Applied Microbiology & Biotechnology (SRCAMB), 142279 Obolensk, Russia.
Olga V KorobovaState Research Center for Applied Microbiology & Biotechnology (SRCAMB), 142279 Obolensk, Russia.
Eugenia S PereskokovaState Research Center for Applied Microbiology & Biotechnology (SRCAMB), 142279 Obolensk, Russia.
Alexander I BorzilovState Research Center for Applied Microbiology & Biotechnology (SRCAMB), 142279 Obolensk, Russia.ORCID 0000-0001-6309-7645
Igor A DyachenkoThe Branch of M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0002-3053-2804
Olga V ShamovaInstitute of Experimental Medicine, WCRC "Center for Personalized Medicine", 197022 St. Petersburg, Russia.ORCID 0000-0002-5168-2801
Yu HuangShenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, Shenzhen 518081, China.ORCID 0000-0002-3875-7581
Qiong ShiShenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI Academy of Marine Sciences, BGI Marine, Shenzhen 518081, China.ORCID 0000-0002-6358-976X
Tatiana V OvchinnikovaM.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-5950-249X
Institute of Bioorganic Chemistry · RUState Research Center for Applied Microbiology and Biotechnology · RUBGI Group (China) · CNInstitute of Experimental Medicine · RUSechenov University · RU

Funding

The Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2021-1049). 075-15-2021-1049
6 · The paper itself

Abstract

Marine polychaetes represent an extremely rich and underexplored source of novel families of antimicrobial peptides (AMPs). The rapid development of next generation sequencing technologies and modern bioinformatics approaches allows us to apply them for characterization of AMP-derived genes and the identification of encoded immune-related peptides with the aid of genome and transcriptome mining. Here, we describe a universal bioinformatic approach based on the conserved BRICHOS domain as a search query for the identification of novel structurally unique AMP families in annelids. In this paper, we report the discovery of 13 novel BRICHOS-related peptides, ranging from 18 to 91 amino acid residues in length, in the cosmopolitan marine worm

Indexed as

Antimicrobial Cationic PeptidesAntimicrobial PeptidesAmino AcidsAnimalsAnti-Bacterial AgentsEscherichia coliMammalsMiceTranscriptomeAmino AcidsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAnnelidaantibiofilm activityantimicrobial peptideantimicrobial resistanceBRICHOS domainHeteromastus filiformismurine modelsPolychaetarecombinant peptidetranscriptome mining

Identifiers

PMID38132960
PMCPMC10745061
OpenAlexW4389784179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.