ReviewMetabolites2023
Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.
Review in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- [Chronic hyperkeratotic plaques on the fingers and axillae in a mother and daughter].Dermatologie (Heidelberg, Germany) · 2026Article
- Efficacy and safety of topical statins for porokeratosis: a systematic review and practice-guided synthesis.Skin health and disease · 2026Review
- [Porokeratosis ptychotropica with mycotic superinfection in a 68-year-old man].Dermatologie (Heidelberg, Germany) · 2026Article
- Article
- Ultraviolet-Induced Fluorescence Dermatoscopy (UVFD) features in Porokeratosis: Findings from a Multicenter Retrospective Study.Dermatology practical & conceptual · 2026Article
- Article
- Rupioid Porokeratosis on the Lower Leg: An Unprecedented Case Report.Clinical, cosmetic and investigational dermatology · 2026Article
- [Multiple squamous cell carcinomas arising in linear porokeratosis].Dermatologie (Heidelberg, Germany) · 2026Article
- Identification of two novelFrontiers in medicine · 2026Article
- Successful Treatment of Linear Porokeratosis with Ivarmacitinib in an Adolescent: A Case Report.Clinical, cosmetic and investigational dermatology · 2026Article
- Topical Treatments for Rare Genetic Dermatological Diseases: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Porokeratosis palmaris et plantaris disseminata: broadening dermoscopic insights in a rare entity.Dermatology online journal · 2025Article
- Ultraviolet-Induced Fluorescence Dermoscopy: Game Changers.The Journal of clinical and aesthetic dermatology · 2025Article
- Article
- Facial follicular porokeratosis simulating discoid lupus erythematosus in an African American woman.JAAD case reports · 2025Article
- A large pruritic plaque in a patient with 2 kidney transplants.JAAD case reports · 2025Article
- Porokeratoses: an update on pathogenesis and treatment.International journal of dermatology · 2025Review
- Porokeratoses-A Rare Group of Dermatoses.Medicina (Kaunas, Lithuania) · 2024Review
- Lipid Abundance and Metabolism Aberrations in Skin Diseases.Metabolites · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid-mevalonate pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.