ArticleBiomimetics (Basel, Switzerland)2023
Unraveling the Mechanism of Platelet Aggregation Suppression by Thioterpenoids: Molecular Docking and In Vivo Antiaggregant Activity.
Liliya E Nikitina, Pavel S Bocharov, Alexander A Ksenofontov, Elena V Antina, Ilmir R Gilfanov, Roman S Pavelyev, Olga V Ostolopovskaya, Inna V Fedyunina, Zulfiya R Azizova, Svetlana V Pestova and 8 more
Abstract read
In one paragraphArticle in Biomimetics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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5 · Who and what moneyAuthors and funding
18 authors.
Liliya E NikitinaGeneral and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0003-2113-5732 Pavel S BocharovG.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 153045 Ivanovo, Russia.ORCID 0000-0001-8833-8089 Alexander A KsenofontovG.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 153045 Ivanovo, Russia.ORCID 0000-0001-8681-0335 Elena V AntinaG.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 153045 Ivanovo, Russia.ORCID 0000-0003-1799-8957 Ilmir R GilfanovInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0003-4351-3378 Roman S PavelyevInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-3195-1218 Olga V OstolopovskayaGeneral and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia.
Inna V FedyuninaGeneral and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0002-6839-8268 Zulfiya R AzizovaGeneral and Organic Chemistry Department, Kazan State Medical University, 420012 Kazan, Russia.
Svetlana V PestovaMedical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 167000 Syktyvkar, Russia.ORCID 0000-0002-8791-5996 Evgeniy S Izmest'evMedical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 167000 Syktyvkar, Russia.ORCID 0000-0001-5698-6292 Svetlana A RubtsovaMedical Chemistry Laboratory, Institute of Chemistry, Komi Scientific Centre, Ural Branch of Russian Academy of Sciences, 167000 Syktyvkar, Russia.ORCID 0000-0003-1224-8751 Sergei V BoichukInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0003-2415-1084 Elena A SmolyarchukDepartment of Pharmacology, Sechenov First Moscow State Medical University (Sechenov University), 125993 Moscow, Russia.
Ilshat G MustafinBiochemistry Department, Kazan State Medical University, 420012 Kazan, Russia.
Airat R KayumovInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0001-7195-1557 Aleksandr V SamorodovDepartment of Pharmacology, Bashkir State Medical University, 450008 Ufa, Russia.ORCID 0000-0001-9302-499X Funding
Kazan State Medical University 58-012-2022Russian Science Foundation 22-73-00337
6 · The paper itselfAbstract
Natural monoterpenes and their derivatives are widely considered the effective ingredients for the design and production of novel biologically active compounds. In this study, by using the molecular docking technique, we examined the effects of two series of "sulfide-sulfoxide-sulfone" thioterpenoids containing different (e.g., bornane and pinane) monoterpene skeletons on the platelet's aggregation. Our data revealed that all the synthesized compounds exhibit inhibitory activities on platelet aggregation. For example, compound
Indexed as
antiaggregant activityintegrin αIIbβ3molecular dockingS-containing monoterpenoids
Identifiers
PMID38132509
PMCPMC10742178
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