ReviewCurrent oncology (Toronto, Ont.)2023
Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review.
Review in Current oncology (Toronto, Ont.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Apolipoprotein E promotes papillary thyroid carcinoma progression by activating PINK1/Parkin-mediated mitophagy.Translational cancer research · 2026Article
- Immunohistochemical expression of Ki-67, INSM1, and SSTR2A in medullary thyroid carcinoma: correlation with tumour size, vascular invasion, and biochemical outcome.Virchows Archiv : an international journal of pathology · 2026Article
- Collision tumor of medullary and papillary thyroid carcinoma with coexisting follicular adenoma: a unique triple pathology case report and review of literature.Annals of medicine and surgery (2012) · 2026Article
- Short- and long-term prognostic analysis of supraclavicular oblique incision versus traditional low-collar incision in thyroidectomy.Endocrine journal · 2026Article
- Article
- Multifocality as a marker of aggressiveness in medullary thyroid carcinoma: a retrospective cohort analysis of lymph node metastasis and recurrence.The oncologist · 2026Article
- A tertiary-center experience of patients with simultaneous medullary and papillary thyroid carcinomas.Hormones (Athens, Greece) · 2026Observational
- Thyroid collision tumor and Graves' disease: A case report and review of literature.World journal of clinical cases · 2026Article
- Synchronous Presence of Papillary, Medullary, and Anaplastic Thyroid Tumors in a Single Patient: A Rare Case Report.The American journal of case reports · 2026Article
- Coexistence of medullary and papillary thyroid carcinoma in the same lobe-isthmus complex: A case report.Bioinformation · 2026Article
- Article
- Coexisting papillary and medullary thyroid carcinomas in a 60 year old male: a case report.Annals of medicine and surgery (2012) · 2025Article
- Synchronous occurrence of papillary thyroid carcinoma and medullary thyroid carcinoma in the setting of Hashimoto's thyroiditis: a case report with literature review.Gland surgery · 2025Article
- Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma.Frontiers in endocrinology · 2025Article
- Coexisting Medullary and Papillary Thyroid Carcinomas: A Case of Dual Neoplasia With a High Risk of Misdiagnosis.Cureus · 2024Article
- The Co-Occurrence of Medullary and Papillary Thyroid Carcinoma-A Literature Review Based on a Case Report.Case reports in endocrinology · 2024Article
- Diagnosis and treatment of a rare bilateral primary thyroid cancer: a case report.Frontiers in oncology · 2024Article
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Authors and funding
14 authors.
Funding
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Abstract
backgroundPapillary thyroid carcinoma (PTC) is the most common type of differentiated TC, while medullary TC (MTC) accounts for 4%. The concomitant presence of PTC and MTC is rare.
methodsThis is a retrospective, single-center observational study conducted over 16 years (2001-2017). The data were collected from the clinical records of patients who underwent total thyroidectomy at the Endocrine Unit-Department of Medicine of the University Hospital of Pisa, Italy.
resultsOver 690 analyzed cases, 650 (94.2%) were exclusive DTC, 19 exclusive MTC (2.75%) and 5 PTC/MTC (0.7%). No case of mixed medullary/follicular TC or hereditary MTC (familial MTC/multiple endocrine neoplasia type 2) was found. Among the five PTC/MTC cases, there was a male prevalence (M:F = 3:2), and all PTC components were at stage I, whereas 40% of MTC were at stage I and III and 20% of MTC were at stage II; microPTC (mPTC) was prevalent (80%) and also microMTCs were frequent (40%); 60% of MTC patients recovered, while 40% of patients developed metastatic disease. The search for germline mutations of the RET gene resulted in being negative in all cases.
conclusionsThe incidence of PTC/MTC has been increasing over the past 30 years. The etiology of PTC/MTC forms is still unknown, and although this simultaneous occurrence could be only a coincidence, we cannot exclude the hypothesis of a shared genetic origin.
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