ArticleBiology2023
The Oxygen-Ozone Adjunct Medical Treatment According to the Protocols from the Italian Scientific Society of Oxygen-Ozone Therapy: How Ozone Applications in the Blood Can Influence Clinical Therapy Success via the Modulation of Cell Biology and Immunity.
Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- SIOOTAntibiotics (Basel, Switzerland) · 2026Article
- Ozone in Botulinum Toxin-Induced Ptosis: Some Comments.Journal of cosmetic dermatology · 2026Article
- Ozone as an Immunomodulator-New Therapeutic Possibilities in the Treatment of Immunodeficiencies-A Narrative Review.Current issues in molecular biology · 2025Review
- How Safe Are Oxygen-Ozone Therapy Procedures for Spine Disc Herniation? The SIOOT Protocols for Treating Spine Disorders.Journal of imaging · 2025Article
- Ozone therapy and the role of the glutathione pathway.Inflammopharmacology · 2025Article
- Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO-1 Pathway.The Kaohsiung journal of medical sciences · 2025Article
- The ability of ozone to counteract multidrug-resistant bacteria if used as an adjunct therapy: a bioinformatic modelling.Journal of medical microbiology · 2025Article
- Short- and Medium-Term effects of major Ozone therapy on disease parameters in fibromyalgia syndrome: A retrospective study.Rheumatology international · 2025Article
- A clinical study on ozone autohemotherapy for the treatment of acute ischemic stroke.Frontiers in medicine · 2025Article
- Effects of Ozone Therapy on Adverse Events and Inflammatory Markers in Patients With Hepatocellular Carcinoma Undergoing Interventional Therapy.Gastroenterology research and practice · 2025Article
- Article
- Ozone Therapy in the Integrated Treatment of Female Dogs with Mammary Cancer: Oxidative Profile and Quality of Life.Antioxidants (Basel, Switzerland) · 2024Article
- Chemical Variations Induced by Ozonization of 5% Glucose Solution and Evaluation of Generated Compounds.Cureus · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOzone is an allotrope of oxygen whose use in medicine has rapidly grown in recent years. Ozonated blood allows for the use of ozone in a safe modality, as plasma and blood cells are endowed with an antioxidant system able to quench ozone's pro-oxidant property and to elicit the Nrf2/Kwap1/ARE pathway.
methodsWe present two clinical studies, a case-series (six patients) observational study adopting ozone as a major autohemotherapy and topical ozone to address infected post-surgical wounds with multi-drug resistant bacteria and an observational study (250 patients) using ozonated blood for treating knee osteoarthritis.
resultsOzonated blood via major autohemotherapy reduced the extent of infections in wounds, reduced the inflammatory biomarkers by more than 75% and improved patients' QoL, whereas ozonated blood via minor autohemotherapy improved significantly (
conclusionsThe models described, i.e., ozone autohemotherapy in wound antimicrobial treatment and ozonated blood in knee osteoarthrosis, following our protocols, share the outstanding ability of ozone to modulate the innate immune response and address bacterial clearance as well as inflammation and pain.
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