Evidence map›Paper›PMID 38132168›Full record

ArticleCells2023

Evaluation of Mono- and Bi-Functional GLOBE-Based Vectors for Therapy of β-Thalassemia by

Lola Koniali, Christina Flouri, Markela I Kostopoulou, Nikoletta Y Papaioannou, Panayiota L Papasavva, Basma Naiisseh, Coralea Stephanou, Anthi Demetriadou, Maria Sitarou, Soteroula Christou and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Lola KonialiDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0003-0438-8770
Christina FlouriGene Expression and Therapy Group, Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Markela I KostopoulouDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.
Nikoletta Y PapaioannouDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0001-9456-5990
Panayiota L PapasavvaDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0003-4410-3119
Basma NaiissehDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.
Coralea StephanouDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0002-2546-6478
Anthi DemetriadouDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0001-7808-0344
Maria SitarouThalassemia Clinic Larnaca, Larnaca General Hospital, 6301 Larnaca, Cyprus.
Soteroula ChristouThalassemia Clinic Nicosia, Archbishop Makarios III Hospital, 1474 Nicosia, Cyprus.
Michael N AntoniouGene Expression and Therapy Group, Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.ORCID 0000-0002-3185-5314
Marina KleanthousDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0003-0064-7034
Petros PatsaliDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0001-8287-6724
Carsten W LedererDepartment of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, 2371 Nicosia, Cyprus.ORCID 0000-0003-3920-9584
Cyprus Institute of Neurology and Genetics · CYGuy's Hospital · GBArchbishop Makarios III Hospital · CYLarnaca College · CY

Funding

EEA and Norway Grants Norway Grants 2014-2021 "New Infrastructure for the Diagnosis and Therapy of Patients"Research and Innovation Foundation of Cyprus EXCELLENCE/0421/0086Research and Innovation Foundation of Cyprus EXCELLENCE/1216/0092Telethon Cyprus PhD Studentship
6 · The paper itself

Abstract

Therapy via the gene addition of the anti-sickling β

Indexed as

beta-ThalassemiaHemoglobinopathiesbeta-GlobinsGenetic TherapyGenetic VectorsHumansMutationRNA InterferenceRNA, Small Interferingbeta-GlobinsRNA, Small Interferinggene therapyhemoglobinopathylentiviral vectorRNA interferenceshRNAmiRsickle cell anemiathalassemia

Identifiers

PMID38132168
PMCPMC10741507
OpenAlexW4389784461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.