Evidence map›Paper›PMID 38132150›Full record

ArticleCells2023

Survivin-Sodium Iodide Symporter Reporter as a Non-Invasive Diagnostic Marker to Differentiate Uterine Leiomyosarcoma from Leiomyoma.

Natalia Garcia, Mara Ulin, Qiwei Yang, Mohamed Ali, Maarten C Bosland, Weiqiao Zeng, Liaohai Chen, Ayman Al-Hendy

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Emerging strategies to reduce the side effects of CAR-T cell therapy: focusing on gene editing and nanotechnology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Current trends in exosomes as therapeutic drug delivery systems.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Natalia GarciaDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.
Mara UlinDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.
Qiwei YangDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-7131-8946
Mohamed AliDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-9675-6691
Maarten C BoslandDepartment of Pathology, University of Illinois at Chicago, Chicago, IL 60607, USA.
Weiqiao ZengDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.
Liaohai ChenDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.
Ayman Al-HendyDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-8778-4447
University of Illinois Chicago · USAin Shams University · EGThe University of Texas Health Science Center at San Antonio · US

Funding

Training the Trainers: Building Institutional Data Science Capacity to Support Health Disparities ResearchU54MD007602 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI Kevin Sean Kimbro · 2018 to 2026
$47.6M
Investigating the effectiveness of COVID-19 testing choices, community engagement, and culturally-embedded mHealth literacy delivery in a medically-underserved, community-based sampleR01ES028615 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AL-HENDY, AYMAN, WALKER, CHERYL L. · 2017 to 2022
$5.0M
Hypovitaminosis D promotes MED12-associated genomic instability in uterine fibroidsR01HD094378 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AL-HENDY, AYMAN, BOYER, THOMAS G · 2018 to 2022
$4.2M
Mechanisms of actions(s) of simvastatin in uterine leiomyomaR01HD094380 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BORAHAY, MOSTAFA A. · 2018 to 2022
$4.0M
Pathological reprogramming of the m6A epitranscriptome in uterine fibroidsR01HD106285 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AL-HENDY, AYMAN, BOYER, THOMAS G · 2021 to 2025
$3.2M
NICHD NIH HHS R01 HD094378NICHD NIH HHS R01 HD094380NICHD NIH HHS R01 HD106285NIEHS NIH HHS R01 ES028615NIH HHS ES028615NIH HHS HD094378NIH HHS HD094380NIH HHS HD106285NIH HHS MD007602NIMHD NIH HHS U54 MD007602
6 · The paper itself

Abstract

Leiomyosarcoma (LMS) has been challenging to diagnose because of limitations in clinical and radiographic predictors, as well as the lack of reliable serum or urinary biomarkers. Most uterine masses consist of benign leiomyoma (LM). However, it is currently a significant challenge in gynecology practice to differentiate LMS from LM. This inability poses grave consequences for patients, leading to a high number of unnecessary hysterectomies, infertility, and other major morbidities and possible mortalities. This study aimed to evaluate the use of Survivin-Sodium iodide symporter (Ad-Sur-NIS) as a reporter gene biomarker to differentiate malignant LMS from benign LM by using an F18-NaBF

Indexed as

Genes, ReporterLeiomyomaLeiomyosarcomaUterine NeoplasmsAnimalsBiomarkersFemaleHumansPositron Emission Tomography Computed TomographySodium-Iodide SymportersSurvivinSymportersBiomarkersSodium-Iodide SymportersSurvivinSymportersPET/CT scanuterine leiomyomauterine leiomyosarcomauterine mass

Identifiers

PMID38132150
PMCPMC10741838
OpenAlexW4389678011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.