Evidence map›Paper›PMID 38132114›Full record

ReviewCells2023

Functions of RNA-Binding Proteins in Cardiovascular Disease.

Grégoire Ruffenach, Lejla Medzikovic, Wasila Sun, Jason Hong, Mansoureh Eghbali

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Perturbation of RNA homeostasis impairs mitochondrial respiration during poxvirus infection through excess RNA accumulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. mExperimental & molecular medicine · 2025
    Review
  10. Review
  11. RNA-Binding Protein Lgals3 , Ferroptosis, and Acute Kidney Injury.Journal of the American Society of Nephrology : JASN · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. RNA-Binding Proteins in Cardiomyopathies.Journal of cardiovascular development and disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Grégoire RuffenachDepartment of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-6419-4332
Lejla MedzikovicDepartment of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Wasila SunDepartment of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0009-0009-6419-5162
Jason HongDepartment of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Mansoureh EghbaliDepartment of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

Role of intestinal inflammation in oxidized lipid induced pulmonary hypertensionR01HL162124 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH, REDDY, SRINIVASA T. · 2022 to 2025
$2.4M
Role of miR125 in pulmonary hypertension secondary to interstitial lung diseaseR01HL147586 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH · 2020 to 2023
$1.9M
Role of Chromosome Y gene, Uty, in protecting against Pulmonary HypertensionR01HL159865 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EGHBALI, MANSOUREH · 2021 to 2024
$1.9M
Integrative Multiomics to Uncover Novel Genes and Networks in Pulmonary Arterial HypertensionK08HL169982 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jason Hong · 2023 to 2026
$706k
NHLBI NIH HHS K08 HL169982NHLBI NIH HHS R01 HL147586NHLBI NIH HHS R01 HL159865NHLBI NIH HHS R01 HL162124
6 · The paper itself

Abstract

Gene expression is under tight regulation from the chromatin structure that regulates gene accessibility by the transcription machinery to protein degradation. At the transcript level, this regulation falls on RNA-binding proteins (RBPs). RBPs are a large and diverse class of proteins involved in all aspects of a transcript's lifecycle: splicing and maturation, localization, stability, and translation. In the past few years, our understanding of the role of RBPs in cardiovascular diseases has expanded. Here, we discuss the general structure and function of RBPs and the latest discoveries of their role in pulmonary and systemic cardiovascular diseases.

Indexed as

Cardiovascular DiseasesHumansRNA-Binding ProteinsRNA SplicingRNA-Binding Proteinscardiovascular diseasespathogenesisRNA binding protein

Identifiers

PMID38132114
PMCPMC10742114
OpenAlexW4389500671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.