ArticleeLife2023
Imaging microglia surveillance during sleep-wake cycles in freely behaving mice.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Microglia stabilize sleep homeostasis via adenosine AScience advances · 2026Article
- Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity.bioRxiv : the preprint server for biology · 2026Article
- Rethinking microglia from a circadian perspective in neuroimmunology: New insights.Neural regeneration research · 2026Article
- Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination.Nature communications · 2026Article
- Neuroimmune Interactions in Neurodegeneration: The Role of Microglia in Alzheimer's and Parkinson's Disease Pathogenesis.Brain sciences · 2026Review
- Research hotspots and trends in the interaction mechanisms of neuroinflammation and sleep disorders: A bibliometric analysis based on WOS.IBRO neuroscience reports · 2025Article
- Contrasting contribution of resident and repopulated brain macrophages in sustaining sleep-wake circuitry.Communications biology · 2025Article
- A versatile miniature two-photon microscope enabling multicolor deep-brain imaging.Nature methods · 2025Article
- Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner.Translational psychiatry · 2025Article
- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- 24-hour simultaneous mPFC's miniature 2-photon imaging, EEG-EMG, and video recording during natural behaviors.Scientific data · 2025Article
- Review
- Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance.Neuron · 2025Article
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- Tuning neural circuits and behaviors by microglia in the adult brain.Trends in neurosciences · 2024Review
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 5 countries.
Funding
Abstract
Microglia surveillance manifests itself as dynamic changes in cell morphology and functional remodeling. Whether and how microglia surveillance is coupled to brain state switches during natural sleep-wake cycles remains unclear. To address this question, we used miniature two-photon microscopy (mTPM) to acquire time-lapse high-resolution microglia images of the somatosensory cortex, along with EEG/EMG recordings and behavioral video, in freely-behaving mice. We uncovered fast and robust brain state-dependent changes in microglia surveillance, occurring in parallel with sleep dynamics and early-onset phagocytic microglial contraction during sleep deprivation stress. We also detected local norepinephrine fluctuation occurring in a sleep state-dependent manner. We showed that the locus coeruleus-norepinephrine system, which is crucial to sleep homeostasis, is required for both sleep state-dependent and stress-induced microglial responses and β
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.