Evidence map›Paper›PMID 38131777›Full record

ArticleBiosensors2023

Controlling the Nucleation and Growth of Salt from Bodily Fluid for Enhanced Biosensing Applications.

Siddharth Srivastava, Yusuke Terai, Jun Liu, Giovanni Capellini, Ya-Hong Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siddharth SrivastavaDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.
Yusuke TeraiDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.
Jun LiuDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.
Giovanni CapelliniIHP-Leibniz Institute for High Performance Microelectronics, 15236 Frankfurt (Oder), Germany.ORCID 0000-0002-5169-2823
Ya-Hong XieDepartment of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.

Funding

AFS/SERS Saliva-based SARS-CoV-2 Earliest Infection and Antibodies DetectionU18TR003778 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HUANG, TONY JUN, KIM, YONG · 2021 to 2022
$1.8M
Acoustofluidic Separation (AFS), Purification and Raman Spectral Fingerprinting of Single EVs: From Cell of Origin to Target Cell and BiofluidsUH3TR002978 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GALL, KENNETH A, HUANG, TONY JUN · 2021 to 2022
$1.8M
NCATS NIH HHS U18 TR003778NCATS NIH HHS UH3 TR002978NIH HHS 4UH3TR002978-03, 1U18TR003778-01
6 · The paper itself

Abstract

Surface-enhanced Raman spectroscopy (SERS) represents a transformative tool in medical diagnostics, particularly for the early detection of key biomarkers such as small extracellular vesicles (sEVs). Its unparalleled sensitivity and compatibility with intricate biological samples make it an ideal candidate for revolutionizing noninvasive diagnostic methods. However, a significant challenge that mars its efficacy is the throughput limitation, primarily anchored in the prerequisite of hotspot and sEV colocalization within a minuscule range. This paper delves deep into this issue, introducing a never-attempted-before approach which harnesses the principles of crystallization-nucleation and growth. By synergistically coupling lasers with plasmonic resonances, we navigate the challenges associated with the analyte droplet drying method and the notorious coffee ring effect. Our method, rooted in a profound understanding of crystallization's materials science, exhibits the potential to significantly increase the areal density of accessible plasmonic hotspots and efficiently guide exosomes to defined regions. In doing so, we not only overcome the throughput challenge but also promise a paradigm shift in the arena of minimally invasive biosensing, ushering in advanced diagnostic capabilities for life-threatening diseases.

Indexed as

Biosensing TechniquesExosomesBiomarkersSodium ChlorideSpectrum Analysis, RamanBiomarkersSodium Chloridebiosensingcrystallizationextracellular vesiclesnucleationplasmonicsSERS

Identifiers

PMID38131777
PMCPMC10741434

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.