Evidence map›Paper›PMID 38131673›Full record

ArticleAntimicrobial agents and chemotherapy2024

Omadacycline pharmacokinetics/pharmacodynamics and efficacy against multidrug-resistant

Sanjay Singh, Tawanda Gumbo, Gunavanthi D Boorgula, Tania A Thomas, Julie V Philley, Shashikant Srivastava

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in microbiology · 2026
    Article
  4. Repurposing drugs to advance the treatment of Buruli ulcer.Antimicrobial agents and chemotherapy · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sanjay SinghDepartment of Medicine, School of Medicine, University of Texas at Tyler, Tyler, Texas, USA.
Tawanda GumboQuantitative Preclinical and Clinical Sciences Department, Praedicare Inc., Dallas, Texas, USA.ORCID 0000-0001-7592-8012
Gunavanthi D BoorgulaDepartment of Medicine, School of Medicine, University of Texas at Tyler, Tyler, Texas, USA.
Tania A ThomasDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Julie V PhilleySection of Pulmonary and Critical Care, School of Medicine, University of Texas at Tyler, Tyler, Texas, USA.
Shashikant SrivastavaDepartment of Medicine, School of Medicine, University of Texas at Tyler, Tyler, Texas, USA.ORCID 0000-0002-8786-8851
The University of Texas at Tyler · USUniversity of Virginia · US

Funding

PK/PD Optimized Cephalosporins Based Treatment Regimens for Children With MDR-TBR01HD099756 · NICHD · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KANT, SHASHI · 2019 to 2023
$1.6M
Reinforcing old warriors to treat Mycobacterium kansasii in shorter durationR21AI148096 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KANT, SHASHI · 2020 to 2021
$413k
NIAID NIH HHS R21 AI148096NICHD NIH HHS R01 HD099756
6 · The paper itself

Abstract

Seventy-five years ago, first-generation tetracyclines demonstrated limited efficacy in the treatment of tuberculosis but were more toxic than efficacious. We performed a series of pharmacokinetic/pharmacodynamic (PK/PD) experiments with a potentially safer third-generation tetracycline, omadacycline, for the treatment of multidrug-resistant tuberculosis (MDR-TB).

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsHumansMicrobial Sensitivity TestsTetracyclinesAntitubercular AgentsomadacyclineTetracyclinesefficacyhollow fiber model systemMDR-TBpharmacokinetics/pharmacodynamicstetracycline

Identifiers

PMID38131673
PMCPMC10848755
OpenAlexW4390104224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.