Evidence map›Paper›PMID 38131671›Full record

ArticleApplied and environmental microbiology2024

Metabolic engineering of

Tania N N Tanwee, Gina L Lipscomb, Jason L Vailionis, Ke Zhang, Ryan G Bing, Hailey C O'Quinn, Farris L Poole, Ying Zhang, Robert M Kelly, Michael W W Adams

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Engineering the hyperthermophilic archaeonApplied and environmental microbiology · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tania N N TanweeDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.ORCID 0009-0005-6795-2879
Gina L LipscombDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Jason L VailionisDepartment of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA.ORCID 0009-0001-9886-2455
Ke ZhangDepartment of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA.
Ryan G BingDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA.
Hailey C O'QuinnDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Farris L PooleDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Ying ZhangDepartment of Cell and Molecular Biology, College of the Environment and Life Sciences, University of Rhode Island, Kingston, Rhode Island, USA.ORCID 0000-0001-8759-0194
Robert M KellyDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA.ORCID 0000-0002-0639-3592
Michael W W AdamsDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-9796-5014

Funding

NC STATE MOLECULAR BIOTECHNOLOGY TRAINING PROGRAM (MBTP)T32GM133366 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Jason M. Haugh, Robert M Kelly · 2020 to 2026
$3.3M
NIGMS NIH HHS T32 GM133366U.S. Department of Energy (DOE) DE-SC0022192
6 · The paper itself

Abstract

The platform chemical 2,3-butanediol (2,3-BDO) is used to derive products, such as 1,3-butadiene and methyl ethyl ketone, for the chemical and fuel production industries. Efficient microbial 2,3-BDO production at industrial scales has not been achieved yet for various reasons, including product inhibition to host organisms, mixed stereospecificity in product formation, and dependence on expensive substrates (i.e., glucose). In this study, we explore engineering of a 2,3-BDO pathway in

Indexed as

Butylene GlycolsCaldicellulosiruptorLactatesMetabolic EngineeringXylansAcetoinBacteriaBase CompositionBiomassCelluloseEubacterialesPhylogenyPlantsRNA, Ribosomal, 16SSequence Analysis, DNASugars2,3-butylene glycolAcetoinalpha-acetolactateButylene GlycolsCelluloseLactatesRNA, Ribosomal, 16SSugarsXylans2,3-butanediolacetoinCaldicellulosiruptor besciilignocellulosemetabolic fluxredox balancethermophile

Identifiers

PMID38131671
PMCPMC10807448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.