Evidence map›Paper›PMID 38131271›Full record

ArticleOrganic & biomolecular chemistry2024

Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes.

Sam Forshaw, Jeremy S Parker, William T Scott, Richard C Knighton, Neelam Tiwari, Samson M Oladeji, Andrew C Stevens, Yean Ming Chew, Jami Reber, Guy J Clarkson and 2 more

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Not So Bioorthogonal Chemistry.Journal of the American Chemical Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sam ForshawDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.ORCID http://orcid.org/0000-0002-8586-4144
Jeremy S ParkerEarly Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, SK10 2NA, UK.ORCID http://orcid.org/0000-0002-4758-3181
William T ScottDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.ORCID http://orcid.org/0009-0004-8774-2935
Richard C KnightonDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.ORCID http://orcid.org/0000-0002-0336-3718
Neelam TiwariDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
Samson M OladejiDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
Andrew C StevensDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.
Yean Ming ChewDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.ORCID http://orcid.org/0009-0003-6342-1822
Jami ReberDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.ORCID http://orcid.org/0000-0002-1825-4303
Guy J ClarksonDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.ORCID http://orcid.org/0000-0003-3076-3191
Mohan K BalasubramanianWarwick Medical School, The University of Warwick, Coventry, CV4 7AL, UK.
Martin WillsDepartment of Chemistry, The University of Warwick, Coventry, CV4 7AL, UK. M.wills@warwick.ac.uk.ORCID http://orcid.org/0000-0002-1646-2379

Funding

Wellcome Trust
6 · The paper itself

Abstract

Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free 'click' reactions. In this paper, a series of functionalised derivatives of this class of reagent, containing fluorescent groups, are described. Studies aimed at understanding and increasing the reactivity of the alkynes are also presented, together with an investigation of the bioconjugation of the reagents with an azide-labelled protein.

Identifiers

PMID38131271
PMCPMC10792613

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.