Evidence map›Paper›PMID 38131105›Full record

ArticleProtein science : a publication of the Protein Society2024

Residues within the LptC transmembrane helix are critical for Escherichia coli LptB

Nicholas P Cina, Dara W Frank, Candice S Klug

Open access · greenAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The LptC transmembrane helix undergoes a rigid body movement upon LptBProtein science : a publication of the Protein Society · 2025
    Article
  3. Article
  4. Residues within the LptC transmembrane helix are critical for Escherichia coli LptBProtein science : a publication of the Protein Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nicholas P CinaDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Dara W FrankDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Candice S KlugDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0003-4547-320X
Medical College of Wisconsin · US

Funding

Lpt protein-mediated transport of LPSR01GM108817 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2014 to 2022
$2.6M
An Automated Microscale Thermophoresis Instrument for Southeastern Wisconsin: a Shared Resource for Biomolecular Interactions and Drug DiscoveryS10OD025036 · OD · MEDICAL COLLEGE OF WISCONSIN · PI HILL, R BLAKE · 2019 to 2019
$582k
NIGMS NIH HHS R01 GM108817NIH HHS S10 OD025036
6 · The paper itself

Abstract

Lipopolysaccharide (LPS) synthesis in Gram-negative bacteria is completed at the outer leaflet of the inner membrane (IM). Following synthesis, seven LPS transport (Lpt) proteins facilitate the movement of LPS to the outer membrane (OM), an essential process that if disrupted at any stage has lethal effects on bacterial viability. LptB

Indexed as

Escherichia coli ProteinsPeriplasmic ProteinsAdenosine TriphosphatasesATP-Binding Cassette TransportersBacterial Outer Membrane ProteinsBiological TransportCarrier ProteinsEscherichia coliLipopolysaccharidesMembrane ProteinsAdenosine TriphosphatasesATP-Binding Cassette TransportersBacterial Outer Membrane ProteinsCarrier ProteinsEscherichia coli ProteinsLipopolysaccharidesLptA protein, E coliLptB protein, E coliLptC protein, E coliMembrane ProteinsPeriplasmic ProteinsABC transporterdifferential scanning fluorimetryEPR spectroscopylipopolysaccharideLPS transportouter membrane biogenesis

Identifiers

PMID38131105
PMCPMC10804673
OpenAlexW4390108726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.