Evidence map›Paper›PMID 38130835›Full record

ArticleFrontiers in neurology2023

Impact of endocrine dysregulation on disability and non-motor symptoms in pediatric onset multiple sclerosis.

Justin Abe, Saba Jafarpour, My H Vu, Devon O'Brien, Natalie K Boyd, Benjamin N Vogel, Lina Nguyen, Kelli C Paulsen, Laura E Saucier, Nusrat Ahsan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Justin AbeJohn A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States.
Saba JafarpourDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
My H VuBiostatistics and Data Management Core, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Devon O'BrienDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Natalie K BoydDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Benjamin N VogelDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Lina NguyenDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Kelli C PaulsenDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Laura E SaucierDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Nusrat AhsanDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Wendy G MitchellDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Jonathan D SantoroDivision of Neurology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Children's Hospital of Los Angeles · USKeck Hospital of USC · USUniversity of Hawaiʻi at Mānoa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pediatric onset multiple sclerosis (POMS) commonly occurs at the time of various endocrine changes. Evaluation of the impact of endocrine status on disease severity in POMS has not been previously explored. Objective: This study sought to evaluate if sex and stress hormones in children with POMS impact motor and non-motor diseases severity. Methods: A single-center case control study was performed. Individuals with POMS were compared to individuals without neurologic disease. Each individual had three blood draws assessing stress and sex hormones between 07:00 and 09:00. Measures of fatigue (Epworth sleepiness scale), depression (PHQ-9), and quality of life (PedsQL) assessed at each visit. Results: Forty individuals with POMS and 40 controls were enrolled. Individuals with POMS had lower free testosterone ( Conclusion: Free testosterone, cortisol, ACTH, and progesterone were abnormal in children with POMS although there was no association between endocrine status and markers of disease severity or non-motor symptoms of MS.

Indexed as

depressionendocrinefatiguehormonesmultiple sclerosispediatric

Identifiers

PMID38130835
PMCPMC10733457
OpenAlexW4389441155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.