Evidence map›Paper›PMID 38130699›Full record

ArticleNature reviews. Methods primers2023

Nanomaterial-based contrast agents.

Jessica C Hsu, Zhongmin Tang, Olga E Eremina, Alexandros Marios Sofias, Twan Lammers, Jonathan F Lovell, Cristina Zavaleta, Weibo Cai, David P Cormode

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Bypassing Heteronuclear MRI: Metal-Free Organosilicon Nanotracers for Background-Free HotspotAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. K-Edge imaging using a clinical dual-source photon-counting CT system.Journal of applied clinical medical physics · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Self-Assembled (Aza)BODIPY Dyes for Biomedical in Vivo Imaging.Angewandte Chemie (International ed. in English) · 2026
    Review
  13. Applications of Nanobiotechnology in Medicine.Life (Basel, Switzerland) · 2026
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica C HsuDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3599-2834
Zhongmin TangDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-1532-8004
Olga E EreminaDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2776-4743
Alexandros Marios SofiasDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-7475-2526
Twan LammersDepartment of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-1090-6805
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, USA.ORCID 0000-0002-9052-884X
Cristina ZavaletaDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-4641-0833
David P CormodeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8391-9500

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Nanoparticle contrast agents for earlier breast cancer detectionR01CA227142 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2018 to 2022
$2.5M
Renally clearable ytterbium nanoparticle contrast agents for spectral photon counting computed tomographyR21EB030373 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2021 to 2022
$447k
NCI NIH HHS R01 CA227142NCI NIH HHS T32 CA009206NIBIB NIH HHS R21 EB030373
6 · The paper itself

Abstract

Medical imaging, which empowers the detection of physiological and pathological processes within living subjects, has a vital role in both preclinical and clinical diagnostics. Contrast agents are often needed to accompany anatomical data with functional information or to provide phenotyping of the disease in question. Many newly emerging contrast agents are based on nanomaterials as their high payloads, unique physicochemical properties, improved sensitivity and multimodality capacity are highly desired for many advanced forms of bioimaging techniques and applications. Here, we review the developments in the field of nanomaterial-based contrast agents. We outline important nanomaterial design considerations and discuss the effect on their physicochemical attributes, contrast properties and biological behaviour. We also describe commonly used approaches for formulating, functionalizing and characterizing these nanomaterials. Key applications are highlighted by categorizing nanomaterials on the basis of their X-ray, magnetic, nuclear, optical and/or photoacoustic contrast properties. Finally, we offer our perspectives on current challenges and emerging research topics as well as expectations for future advancements in the field.

Identifiers

PMID38130699
PMCPMC10732545

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.