Evidence map›Paper›PMID 38130475›Full record

ArticleACS catalysis2023

Catalytic Mechanism of Nonglycosidic C-N Bond Formation by the Pseudoglycosyltransferase Enzyme VldE.

Takeshi Tsunoda, Hatem A Abuelizz, Arash Samadi, Chin Piow Wong, Takayoshi Awakawa, Corey J Brumsted, Ikuro Abe, Taifo Mahmud

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. NonglycosidicSynthetic and systems biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Takeshi TsunodaDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331-3507, U.S.A.ORCID 0000-0001-9639-526X
Hatem A AbuelizzDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331-3507, U.S.A.
Arash SamadiDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331-3507, U.S.A.
Chin Piow WongGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Takayoshi AwakawaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Corey J BrumstedDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331-3507, U.S.A.
Ikuro AbeGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Taifo MahmudDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331-3507, U.S.A.
Oregon State University · USThe University of Tokyo · JP

Funding

Research Training in Natural Product Complementary and Integrative Health - Diversity Supplement to T32 Predoctoral Training GrantT32AT010131 · NCCIH · OREGON STATE UNIVERSITY · PI TAIFO MAHMUD, RICHARD B VAN BREEMEN · 2020 to 2026
$1.8M
Biosynthetic studies and development of ribomimetic-based anti-infectivesR01AI129957 · NIAID · OREGON STATE UNIVERSITY · PI MAHMUD, TAIFO · 2018 to 2022
$1.8M
Biochemical and Mechanistic Studies of PseudoglycosyltransferasesR15GM112068 · NIGMS · OREGON STATE UNIVERSITY · PI MAHMUD, TAIFO · 2014 to 2014
$312k
NCCIH NIH HHS T32 AT010131NIAID NIH HHS R01 AI129957NIGMS NIH HHS R15 GM112068
6 · The paper itself

Abstract

The pseudoglycosyltransferase (PsGT) enzyme VldE is a homologue of the retaining glycosyltransferase (GT) trehalose 6-phosphate synthase (OtsA) that catalyzes a coupling reaction between two pseudo-sugar units, GDP-valienol and validamine 7-phosphate, to give a product with α,α-

Indexed as

chimeric proteinC-N bond formationkinetic isotope effectpseudoglycosyltransferaseSNi mechanismvalidamycin

Identifiers

PMID38130475
PMCPMC10732325
OpenAlexW4387311756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.