Evidence map›Paper›PMID 38130450›Full record

ArticleJournal of veterinary research2023

Study on the expression of testin in the testes of dogs.

Rafał Ciaputa, Marcin Nowak, Stanisław Dzimira, Eleonora Brambilla, Małgorzata Kandefer-Gola, Alicja Tomaszek, Aneta Popiel-Kopaczyk, Piotr Dzięgiel, Valeria Grieco

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Rafał CiaputaDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID https://orcid.org/0000-0002-8816-7723
Marcin NowakDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID https://orcid.org/0000-0002-2468-107X
Stanisław DzimiraDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID https://orcid.org/0000-0001-7203-2392
Eleonora BrambillaDepartment of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, Italy.ORCID https://orcid.org/0000-0002-4071-242X
Małgorzata Kandefer-GolaDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID https://orcid.org/0000-0002-2198-8877
Alicja TomaszekDepartment of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.ORCID https://orcid.org/0000-0001-8086-7760
Aneta Popiel-KopaczykDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wrocław Medical University, 50-368 Wrocław, Poland.ORCID https://orcid.org/0000-0001-5746-4824
Piotr DzięgielDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wrocław Medical University, 50-368 Wrocław, Poland.ORCID https://orcid.org/0000-0002-8292-1385
Valeria GriecoDepartment of Veterinary Medicine and Animal Science, University of Milan, 26900 Lodi, Italy.ORCID https://orcid.org/0000-0002-9445-4235
Wrocław University of Environmental and Life Sciences · PLUniversity of Milan · ITWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Testin is a protein involved in cell mobility, adhesion and colony formation. In rats, testin presence has been reported in the testes, and its possible role in spermatogenesis has been suggested. Studies in humans also suggest a possible role of testin as a cancer suppressor protein. In the dog, which represents both an important pet species and a good animal model for studying biological and pathological testicular processes, the presence of testin has never been reported. Material and Methods: In the present study, the expression of testin in foetal, prepubertal, adult and aged canine testes was investigated. Testes from 5 adult and 3 aged dogs, from 2 one-month-old puppies and from 2 foetuses miscarried at the end of pregnancy were immunohistochemically examined with a commercial antibody against testin. Results: Testin was intensely expressed in Sertoli cells in every testis examined. Spermatids were also positive for testin in mature dogs and in the testicular areas of the aged ones which were not atrophic. Weak expression of testin was also detected in all testes examined. Conclusion: The present study, the first demonstrating the presence of testin in canine testes, provides the basis for further dog-human comparative research and for studies on the role of this protein in canine physiology, reproduction and testicular pathologies.

Indexed as

dogimmunohistochemistryTES genetestestestin

Identifiers

PMID38130450
PMCPMC10730544
OpenAlexW4388086807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.