Evidence map›Paper›PMID 38130373›Full record

ArticleMolecular therapy. Nucleic acids2024

Neuronal-type-specific epigenome editing to decrease

Zhiguo Sun, Boris Kantor, Ornit Chiba-Falek

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Epigenetic editing: from concept to clinic.Nature reviews. Drug discovery · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. An Overview of Epigenetic Changes in the Parkinson's Disease Brain.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhiguo SunCLAIRIgene, LLC, Durham, NC 27701, USA.
Boris KantorViral Vector Core, Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Ornit Chiba-FalekDivision of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.
Duke University · USClairvoyant Technology (United States) · US

Funding

Lewy body neuropathologies and SNCA gene: variants expression and splicingRF1NS113548 · NINDS · DUKE UNIVERSITY · PI CHIBA-FALEK, ORNIT · 2020 to 2020
$3.8M
NINDS NIH HHS RF1 NS113548
6 · The paper itself

Abstract

Overexpression of

Indexed as

alpha-synucleincholinergic neurondementia with Lewy bodiesDLBdopaminergic neuronsepigenetic editinggene therapyhiPSChuman induced pluripotent stem cellslentivirus vectorsMT: RNA/DNA editingParkinson’s diseasePDSNCAsynucleinopathies

Identifiers

PMID38130373
PMCPMC10732167
OpenAlexW4388979462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.