Evidence map›Paper›PMID 38129964›Full record

ArticleAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2024

Addressing the rising trend of high-risk pulmonary embolism mortality: Clinical and research priorities.

Scott D Casey, William B Stubblefield, Dieuwke Luijten, Frederikus A Klok, Lauren M Westafer, David R Vinson, Christopher Kabrhel

Abstract read
In one paragraph

Article in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Scott D CaseyKaiser Permanente Division of Research, Oakland, California, USA.ORCID 0000-0001-6733-2155
William B StubblefieldDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-3817-1414
Dieuwke LuijtenDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medicine Center, Leiden, Netherlands.ORCID 0000-0003-4776-0587
Frederikus A KlokDepartment of Medicine-Thrombosis and Hemostasis, Leiden University Medicine Center, Leiden, Netherlands.
Lauren M WestaferDepartment of Emergency Medicine, UMASS Chan Medical School-Baystate, Springfield, Massachusetts, USA.ORCID 0000-0003-2292-045X
David R VinsonKaiser Permanente Division of Research, Oakland, California, USA.ORCID 0000-0001-6559-1858
Christopher KabrhelDepartment of Emergency Medicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-8699-7176

Funding

Supplemental Oxygen for Pulmonary Embolism (SO-PE) - A Mechanistic Clinical TrialR01HL168040 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER KABRHEL · 2023 to 2026
$2.3M
NHLBI NIH HHS R01 HL168040
6 · The paper itself

Abstract

backgroundDeaths from high-risk pulmonary embolism (PE) appear to have increased in the US over the last decade. Modifiable risks contributing to this worrisome trend present opportunities for physicians, researchers, and healthcare policymakers to improve care.

methodsWe sought to contextualize contemporary, high-risk PE epidemiology and examine clinical trials, quality improvement opportunities, and healthcare policy initiatives directed at reducing mortality.

resultsWe observed significant and modifiable excess mortality due to high-risk PE. We identified several opportunities to improve care including: (1) rapid translation of forthcoming data on reperfusion strategies into clinical practice; (2) improved risk stratification tools; (3) quality improvement initiatives to address presumptive anticoagulation practice gaps; and (3) adoption of health policy initiatives to establish pulmonary embolism response teams and address the social determinants of health.

conclusionAddressing knowledge and practice gaps in intermediate and high-risk PE management must be prioritized and informed by forthcoming high-quality data. Implementation efforts are needed to improve acute PE management and resolve treatment disparities.

Indexed as

Fibrinolytic AgentsPulmonary EmbolismHumansResearchThrombolytic TherapyTreatment OutcomeFibrinolytic Agentscatheter directed thrombolysishealth care disparitiespulmonary embolismquality improvementsystemic thrombolysis

Identifiers

PMID38129964
PMCPMC12043283

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.