Evidence map›Paper›PMID 38129868›Full record

ArticleChild and adolescent psychiatry and mental health2023

The cost-utility of an intervention for children and adolescents with a parent having a mental illness in the framework of the German health and social care system: a health economic evaluation of a randomized controlled trial.

Tamara Waldmann, Jochen Schaible, Maja Stiawa, Thomas Becker, Karl Wegscheider, Bonnie Adema, Silke Wiegand-Grefe, Reinhold Kilian

Registry-linked trialAbstract read
In one paragraph

Article in Child and adolescent psychiatry and mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02308462 (Implementation and Evaluation of a Family-based Intervention Program for Children and Adolescents of Mentally Ill Parents - a Randomized Controlled Multicenter Trial), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02308462 nacompletednot on this map

Implementation and Evaluation of a Family-based Intervention Program for Children and Adolescents of Mentally Ill Parents - a Randomized Controlled Multicenter Trial

TypeinterventionalSponsorSilke Wiegand-Grefe, Prof. Dr.Ran2014 to 2019Enrolled400ConditionsSchizophrenia and Disorders With Psychotic Features, Mood Disorders, Neurotic Disorders, Personality DisordersArmsCHIMPS intervention
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tamara WaldmannDepartment of Psychiatry and Psychotherapy at BKH Günzburg II, Ulm University, Lindenallee 2, 89312, Günzburg, Germany.
Jochen SchaibleDepartment of Psychiatry and Psychotherapy at BKH Günzburg II, Ulm University, Lindenallee 2, 89312, Günzburg, Germany.
Maja StiawaDepartment of Psychiatry and Psychotherapy at BKH Günzburg II, Ulm University, Lindenallee 2, 89312, Günzburg, Germany.
Thomas BeckerDepartment of Psychiatry and Psychotherapy at BKH Günzburg II, Ulm University, Lindenallee 2, 89312, Günzburg, Germany.
Karl WegscheiderInstitute for Medical Biometry and Epidemiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Bonnie AdemaDepartment for Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Silke Wiegand-GrefeDepartment for Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Reinhold KilianDepartment of Psychiatry and Psychotherapy at BKH Günzburg II, Ulm University, Lindenallee 2, 89312, Günzburg, Germany. reinhold.kilian@uni-ulm.de.

Funding

German Federal Ministry of Education and Research (BMBF) O1GY1337
6 · The paper itself

Abstract

backgroundChildren of families with a parent with a mental illness have an increased risk of developing social and mental health problems resulting in decreased quality of life. Therefore, children and adolescents living in families with a parent with mental illness are regarded as a target group for preventive interventions. To date, only a few economic evaluation studies for interventions directed at preventing the intergenerational transmission of mental health problems exist. In this investigation we estimated the cost utility of an intervention for the support of children and adolescents with a parent having a mental illness from the perspective of the German health and social care system.

methodsWe randomly assigned a total of 214 families with 337 children and adolescents to the intervention (INT) group (108/170) or the control (TAU) group (106/167). Families in the intervention group received on average eight intervention sessions (50-90 min) over 6 months. We estimated total cost of illness by means of the Children and Adolescent Mental Health Service Receipt Inventory (CAMHSRI) over 24 months. For the estimation of Quality-Adjusted Live Years (QALYs) we applied the KIDSCREEN-10. For estimating the incremental cost-utility of the intervention compared to treatment as usual we used the net-benefit approach.

resultsWe estimated the annual cost of illness amounting to € 3784.59 (SD € 8581.11) in the TAU group and € 3264.44 (SD € 9431.89) in the INT group. The annual cost difference between INT and TAU was € - 516.14 (SE 1124.95) which was not significant (p ≤ 0.05). We estimated the average QALY to be 0.759 (SD 0.073) in the TAU group and 0.763 (SD 0.072). The QALY difference between INT and TAU was 0.0037 (SE 0.0092) which was not significant (p ≤ 0.05). The incremental cost utility ratio (ICUR) indicated that the gain of one additional year in full health by means of the intervention was associated with the saving of € 139.49. However, the stochastic insecurity of the ICUR did not allow a unique decision about the cost-utility of the intervention.

conclusionsMore information on the economic value of the intervention for families with a parent with mental illness in comparison to treatment as usual in Germany is needed.

trial registrationClinicalTrials.gov, identifier NCT02308462; German Clinical Trials Register: DRKS00006806.

Indexed as

AdolescentsChildrenCost-utilityHealth economic evaluationParent with mental illness with mental illnessSelective prevention

Identifiers

PMID38129868
PMCPMC10740235

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.