Evidence map›Paper›PMID 38129775›Full record

Trial reportBMC geriatrics2023

Memory support training and lifestyle modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention (Brain Boosters).

S Tomaszewski Farias, J Fox, H Dulaney, M Chan, S Namboodiri, D J Harvey, A Weakley, S Rahman, C Luna, B F Beech and 2 more

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05027789 (Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's Disease), which is not on this map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05027789 naactive not recruitingnot on this map

Compensation Training and Lifestyle Modifications to Promote Healthy Aging in Persons at Risk for Alzheimer's Disease: a Digital Application Supported Intervention (Brain Boosters 2)

TypeinterventionalSponsorUniversity of California, DavisRan2021 to 2026Enrolled263ConditionsMemory Disorders, Cognitive ImpairmentArmsSelf-Guided, Structured Group
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Clarifying healthy aging: building a common language for policy innovation within the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

S Tomaszewski FariasDepartment of Neurology, University of California, Davis, Sacramento, USA. farias@ucdavis.edu.
J FoxDepartment of Neurology, University of California, Davis, Sacramento, USA.
H DulaneyDepartment of Neurology, University of California, Davis, Sacramento, USA.
M ChanDepartment of Neurology, University of California, Davis, Sacramento, USA.
S NamboodiriDepartment of Neurology, University of California, Davis, Sacramento, USA.
D J HarveyDepartment of Biostatistics, University of California, Davis, Davis, USA.
A WeakleyDepartment of Neurology, University of California, Davis, Sacramento, USA.
S RahmanDepartment of Psychology, Washington State University, Pullman, USA.
C LunaDepartment of Psychology, Washington State University, Pullman, USA.
B F BeechDepartment of Psychology, Washington State University, Pullman, USA.
L CampbellDepartment of Neurology, University of California, Davis, Sacramento, USA.
M Schmitter-EdgecombeDepartment of Psychology, Washington State University, Pullman, USA.
University of California, Davis · USWashington State University · US

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported interventionR01AG066748 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMITTER-EDGECOMBE, MAUREEN, TOMASZEWSKI-FARIAS, SARAH E · 2021 to 2025
$4.2M
NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG066748NIH HHS R01 AG066748
6 · The paper itself

Abstract

backgroundEvidence-based interventions to protect against cognitive decline among older adults at risk for Alzheimer's disease and related dementias (ADRD) are urgently needed. Rehabilitation approaches to support memory and behavioral/lifestyle interventions are recognized as promising strategies for preserving or improving cognitive health, although few previous interventions have combined both approaches. This paper describes the protocol of the Brain Boosters intervention, which synergistically combines training in compensatory and healthy lifestyle behaviors and supports implementation and tracking of new behaviors with a digital application.

methodsThe study utilizes a single-site, single-blinded, randomized controlled design to compare a structured lifestyle and compensatory aid intervention to an education-only self-guided intervention. We plan to enroll 225 community-dwelling adults (25% from underrepresented groups) aged 65 + who endorse subjective cognitive decline (SCD) and low baseline levels of healthy lifestyle behaviors. Both interventions will be administered in group format, consisting of 15 two-hour classes that occur weekly for ten weeks and taper to bi-monthly and monthly, for an intervention duration of 6 months. Participants in both interventions will receive education about a variety of memory support strategies and healthy lifestyle behaviors, focusing on physical and cognitive activity and stress management. The structured intervention will also receive support in adopting new behaviors and tracking set goals aided by the Electronic Memory and Management Aid (EMMA) digital application. Primary outcomes include global cognition (composite of memory, attention, and executive function tests) and everyday function (Everyday Cognition Questionnaire). Data will be collected at baseline and outcome visits, at approximately 6, 12, and 18 months. Qualitative interviews, self-report surveys (e.g., indicators of self-determination, health literacy) and EMMA data metrics will also be used to identify what components of the intervention are most effective and for whom they work. DISCUSSION: Successful project completion will provide valuable information about how individuals with SCD respond to a compensation and preventative lifestyle intervention assisted by a digital application, including an understanding of factors that may impact outcomes, treatment uptake, and adherence. The work will also inform development, scaling, and personalization of future interventions that can delay disability in individuals at risk for ADRD.

trial registrationClinicalTrials.gov. (NCT05027789, posted 8/30/2021).

Indexed as

Alzheimer DiseaseCognitive DysfunctionHealthy AgingAgedBrainCognitionHumansLife StyleSingle-Blind MethodAlzheimer’s diseaseBehavioral interventionCognitive impairmentDementiaDementia preventionLifestyleMemory supportMultidomain interventionPreventionProtocolRehabilitationSubjective cognitive concernSubjective cognitive decline

Identifiers

PMID38129775
PMCPMC10740219
OpenAlexW4390049573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.