ArticleNeuroradiology2024
Impaired glymphatic system revealed by DTI-ALPS in cerebral palsy due to periventricular leukomalacia: relation with brain lesion burden and hand dysfunction.
Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review.PloS one · 2025Pooled it
- DTI-ALPS as a marker of glymphatic function: Review of the literature findings, methodology, and interpretation.Neuroimage. Reports · 2026Article
- White matter microstructural and network abnormalities in periventricular leukomalacia and their association with motor severity.Neuroradiology · 2026Article
- Disrupted age-related glymphatic patterns in children with deep gray matter hypoxic-ischemic encephalopathy: a diffusion tensor imaging analysis along the perivascular space study.Neuroradiology · 2026Article
- Investigating the DTI-ALPS index and its association with cognitive impairment in Alzheimer's disease: a diffusion tensor imaging study.Frontiers in neuroscience · 2026Article
- Association between movement impairments and glymphatic system dysfunction in spastic diplegic cerebral palsy using DTI-ALPS.Neuroradiology · 2025Article
- Widespread and prolonged pain may reduce brain clearance capacity only via sleep impairment: Evidence from participants with knee pain.The journal of pain · 2025Article
- Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements.NMR in biomedicine · 2024Review
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePreterm children with cerebral palsy (CP) often have varying hand dysfunction, while the specific brain injury with periventricular leukomalacia (PVL) cannot quite explain its mechanism. We aimed to investigate glymphatic activity using diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and evaluate its association with brain lesion burden and hand dysfunction in children with CP secondary to PVL.
methodsWe retrospectively enrolled 18 children with bilateral spastic CP due to PVL and 29 age- and sex-matched typically developing controls. The Manual Ability Classification System (MACS) was used to assess severity of hand dysfunction in CP. A mediation model was performed to explore the relationship among the DTI-ALPS index, brain lesion burden, and the MACS level in children with CP.
resultsThere were significant differences in the DTI-ALPS index between children with CP and their typically developing peers. The DTI-ALPS index of the children with CP was lower than that of the controls (1.448 vs. 1.625, P = 0.003). The mediation analysis showed that the DTI-ALPS index fully mediated the relationship between brain lesion burden and the MACS level (c' = 0.061, P = 0.665), explaining 80% of the effect.
conclusionThis study provides new insights into the neural basis of hand dysfunction in children with CP, demonstrating an important role of glymphatic impairment in such patients. These results suggest that PVL might affect hand function in children with CP by disrupting glymphatic drainage.
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