Evidence map›Paper›PMID 38129558›Full record

ArticleScientific reports2023

Muscle diffusion MRI reveals autophagic buildup in a mouse model for Pompe disease.

Marlena Rohm, Gabriele Russo, Xavier Helluy, Martijn Froeling, Vincent Umathum, Nicolina Südkamp, Denise Manahan-Vaughan, Robert Rehmann, Johannes Forsting, Frank Jacobsen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Marlena RohmDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Gabriele RussoDepartment of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801, Bochum, Germany.
Xavier HelluyDepartment of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801, Bochum, Germany.
Martijn FroelingDepartment of Radiology, University Medical Centre Utrecht, 3584 CX, Utrecht, The Netherlands.
Vincent UmathumInstitute of Neuropathology, Justus Liebig University, 35390, Giessen, Germany.
Nicolina SüdkampDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Denise Manahan-VaughanDepartment of Neurophysiology, Medical Faculty, Ruhr-University Bochum, 44801, Bochum, Germany.
Robert RehmannDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Johannes ForstingDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Frank JacobsenDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Andreas RoosDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Yoon ShinMolecular Genetic and Metabolism Laboratory, 80333, Munic, Germany.
Anne SchänzerInstitute of Neuropathology, Justus Liebig University, 35390, Giessen, Germany.
Matthias VorgerdDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Lara SchlaffkeDepartment of Neurology, Berufsgenossenschaftliches-University Hospital Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. lara.schlaffke@rub.de.
BG University Hospital Bergmannsheil Bochum · DERuhr University Bochum · DEJustus-Liebig-Universität Gießen · DEUniversity Children's Hospital Tübingen · DEUniversity Medical Center Utrecht · NLUniversity of Duisburg-Essen · DE

Funding

Deutsche Forschungsgemeinschaft 122679504 - TPA5Deutsche Gesellschaft für Muskelkranke GU1/2Medizinische Fakultät, Ruhr-Universität Bochum FoRUM F960R-2020NWO-AES 18929
6 · The paper itself

Abstract

Quantitative muscle MRI is increasingly important in the non-invasive evaluation of neuromuscular disorders and their progression. Underlying histopathotological alterations, leading to changes in qMRI parameters are incompletely unraveled. Early microstructural differences of unknown origin reflected by Diffusion MRI in non-fat infiltrated muscles were detected in Pompe patients. This study employed a longitudinal approach with a Pompe disease mouse model to investigate the histopathological basis of these changes. Monthly scans of Pompe (Gaa

Indexed as

Glycogen Storage Disease Type IIAnimalsDiffusion Magnetic Resonance ImagingDisease Models, AnimalHumansInfantMiceMuscle Fibers, SkeletalQuadriceps MuscleWaterWater

Identifiers

PMID38129558
PMCPMC10739793
OpenAlexW4390057484

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.