ArticleNature communications2023
Asymmetric coding of reward prediction errors in human insula and dorsomedial prefrontal cortex.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory.bioRxiv : the preprint server for biology · 2026Article
- A ventral striatal learning signal reflecting individual differences in the success of fear extinction.Molecular psychiatry · 2026Article
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- Insights into effortful adaptation during speech perception: The role of dopamine, norepinephrine, and prediction error.Cognitive, affective & behavioral neuroscience · 2026Review
- Brain network localization of anhedonia.Translational psychiatry · 2026Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Neural self-organization during episodic encoding: deep recurrent effective connectivity from source-localized EEG.Frontiers in psychology · 2026Article
- Neural Dynamics of Social Cognition: A Single-Trial Computational Analysis of Learning Under Uncertainty.Human brain mapping · 2026Article
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Tachykinin 1-expressing neurons in the lateral habenula signal negative reward prediction error.bioRxiv : the preprint server for biology · 2025Article
- Changes in Rest-Activity Rhythms in Adolescents as They Age: Associations With Brain and Behavioral Changes in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Predictive encoding of auditory sequences in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Neural and computational evidence for a predictive learning account of the testing effect.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanically adaptive and deployable intracortical probes enable long-term neural electrophysiological recordings.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Changes in rest-activity rhythms in adolescents as they age: associations with brain changes and behavior in the ABCD study.medRxiv : the preprint server for health sciences · 2024Article
- Temporally organized representations of reward and risk in the human brain.Nature communications · 2024Article
- Asymmetric coding of reward prediction errors in human insula and dorsomedial prefrontal cortex.Nature communications · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The signed value and unsigned salience of reward prediction errors (RPEs) are critical to understanding reinforcement learning (RL) and cognitive control. Dorsomedial prefrontal cortex (dMPFC) and insula (INS) are key regions for integrating reward and surprise information, but conflicting evidence for both signed and unsigned activity has led to multiple proposals for the nature of RPE representations in these brain areas. Recently developed RL models allow neurons to respond differently to positive and negative RPEs. Here, we use intracranially recorded high frequency activity (HFA) to test whether this flexible asymmetric coding strategy captures RPE coding diversity in human INS and dMPFC. At the region level, we found a bias towards positive RPEs in both areas which paralleled behavioral adaptation. At the local level, we found spatially interleaved neural populations responding to unsigned RPE salience and valence-specific positive and negative RPEs. Furthermore, directional connectivity estimates revealed a leading role of INS in communicating positive and unsigned RPEs to dMPFC. These findings support asymmetric coding across distinct but intermingled neural populations as a core principle of RPE processing and inform theories of the role of dMPFC and INS in RL and cognitive control.
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