Evidence map›Paper›PMID 38129427›Full record

ReviewNature reviews. Disease primers2023

Central neuropathic pain.

Jan Rosner, Daniel C de Andrade, Karen D Davis, Sylvia M Gustin, John L K Kramer, Rebecca P Seal, Nanna B Finnerup

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07342777 (EXpain - Is Exercise an Effective Non-pharmacological Analgesic Treatment in People With Multiple Sclerosis?), which is not on this map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07342777 narecruitingnot on this mapstarted 2026, after this paper: background citation

EXpain - Is Exercise an Effective Non-pharmacological Analgesic Treatment in People With Multiple Sclerosis?

TypeinterventionalSponsorUniversity of AarhusRan2026 to 2028Enrolled116ConditionsMultiple Sclerosis, Chronic Pain, Neuropathic PainArmsProgressive resistance exercise, Usual Care followed by progressive resistance exercise
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Resonance massage tool effects in non-migraine headache management.Journal of oral & facial pain and headache · 2025
    Trial
  6. Trial
  7. Trial
  8. Article
  9. Progress in pain mechanisms and management.Signal transduction and targeted therapy · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. A hematoma location-based nomogram for individualized prediction of thalamic pain after spontaneous thalamic hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 5 countries.

Jan RosnerDanish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Daniel C de AndradeCenter for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Karen D DavisDivision of Brain, Imaging and Behaviour, Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Sylvia M GustinCentre for Pain IMPACT, Neuroscience Research Australia, Sydney, New South Wales, Australia.
John L K KramerInternational Collaboration on Repair Discoveries, ICORD, University of British Columbia, Vancouver, Canada.
Rebecca P SealPittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nanna B FinnerupDanish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. finnerup@clin.au.dk.ORCID 0000-0001-5541-0240
Aalborg University · DKAarhus University Hospital · DKUniversity Health Network · CAUniversity of Bern · CHUniversity of British Columbia · CAUniversity of Pittsburgh · USUNSW Sydney · AU

Funding

Dorsal horn circuits for mechanical allodyniaR01NS107364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2019 to 2022
$2.1M
Cell-type specific molecular and functional analyses to target dorsal horn pain circuitry in mice and non-human primatesR56NS133364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PFENNING, ANDREAS ROBERT, SEAL, REBECCA P · 2023 to 2023
$499k
Molecular and functional organization of the dorsal horn in mouse and non-human primateR21NS109792 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEAL, REBECCA P · 2018 to 2019
$413k
NINDS NIH HHS R01 NS107364NINDS NIH HHS R21 NS109792NINDS NIH HHS R56 NS133364
6 · The paper itself

Abstract

Central neuropathic pain arises from a lesion or disease of the central somatosensory nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related neuroinflammatory conditions. The incidence of central neuropathic pain differs based on its underlying cause. Individuals with spinal cord injury are at the highest risk; however, central post-stroke pain is the most prevalent form of central neuropathic pain worldwide. The mechanisms that underlie central neuropathic pain are not fully understood, but the pathophysiology likely involves intricate interactions and maladaptive plasticity within spinal circuits and brain circuits associated with nociception and antinociception coupled with neuronal hyperexcitability. Modulation of neuronal activity, neuron-glia and neuro-immune interactions and targeting pain-related alterations in brain connectivity, represent potential therapeutic approaches. Current evidence-based pharmacological treatments include antidepressants and gabapentinoids as first-line options. Non-pharmacological pain management options include self-management strategies, exercise and neuromodulation. A comprehensive pain history and clinical examination form the foundation of central neuropathic pain classification, identification of potential risk factors and stratification of patients for clinical trials. Advanced neurophysiological and neuroimaging techniques hold promise to improve the understanding of mechanisms that underlie central neuropathic pain and as predictive biomarkers of treatment outcome.

Indexed as

Multiple SclerosisNeuralgiaSpinal Cord InjuriesAntidepressive AgentsHumansPain ManagementAntidepressive Agents

Identifiers

PMID38129427
PMCPMC11329872
OpenAlexW4390062520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.