ArticleJournal of cachexia, sarcopenia and muscle2024
Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture.
Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Prognostic assessment of sarcopenia in patients with fractures: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Sarcopenia index is a superior prognostic marker to creatinine-cystatin C ratio in older adults with hip fracture.Journal of orthopaedic surgery and research · 2025Article
- The influence of muscle size and density, as well as subcutaneous adipose tissue, on mortality risk in elderly women across different age groups.BMC musculoskeletal disorders · 2025Article
- The size and density of muscle and subcutaneous adipose tissue are independently associated with the risk of mortality in older women with different hip fracture types.Journal of orthopaedic surgery and research · 2025Article
- Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture.Journal of cachexia, sarcopenia and muscle · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough sarcopenia has been recognized as a predictor of mortality in elderly patients with hip fracture, the association of thigh fat and muscle with cardiovascular (CV) outcome remains unclear. We examined the impact of computed tomography (CT)-derived shape features of thigh fat and muscle on major adverse CV events (MACE) in elderly patients with hip fracture.
methodsWe conducted a retrospective analysis of consecutive patients aged ≥65 years who presented with hip fracture confirmed on pelvic bone CT scan and underwent hip fracture surgery at our institution from April 2019 to December 2021. The cross-sectional area (CSA) and compactness (CM) of both the muscle and fat at the upper-thigh level were calculated from two-dimensional CT images using AVIEW Research (v1.1.38, Coreline Soft, Co. Ltd, Seoul, South Korea). The shape features of thigh fat and muscle were categorized into four groups based on the combination of CSA and CM: fat CSA (fat area [FA])/fat CM (FCM), muscle CSA (muscle area [MA])/muscle CM (MCM), FA/MCM and MA/FCM. In each of them, subjects were categorized into four subgroups: high CSA/high CM, high CSA/low CM, low CSA/high CM and low CSA/low CM. The primary outcome was MACE after 30 days of surgery, defined as a composite of all-cause death, acute myocardial infarction, stroke or hospitalization for heart failure.
resultsOf 356 patients enrolled (median age, 82 years; 76.7% females), 72 (20.2%) had MACE over a median follow-up of 13.1 months (ranges 5.9-21.0 months). Patients with MACE had a significantly lower median FA (193.7 vs. 226.2 cm
conclusionsIn elderly patients with fragility hip fracture, thigh CT-derived measures of FA and FCM may provide useful prognostic information for predicting adverse CV outcomes.
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