Evidence map›Paper›PMID 38128735›Full record

ArticleNeurotoxicology2024

Synchrotron speciation of umbilical cord mercury and selenium after environmental exposure in Niigata.

Monica Weng, Natalia V Dolgova, Linda I Vogt, Muhammad Qureshi, Dimosthenis Sokaras, Thomas Kroll, Hisashi Saitō, John L O'Donoghue, Gene E Watson, Gary J Myers and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Monica WengDepartment of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada.
Natalia V DolgovaCalibr - California Institute for Biomedical Research, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Linda I VogtDepartment of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada.
Muhammad QureshiStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
Dimosthenis SokarasStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
Thomas KrollStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA.
Hisashi SaitōKido Hospital, Niigata, Japan.
John L O'DonoghueDepartment of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Gene E WatsonDepartment of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA; Eastman Institute for Oral Health, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Gary J MyersDepartment of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA; Departments of Neurology and Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Tomoko SekikawaDepartment of Internal Medicine, Nuttari Clinic, 6-4-12 Nuttarihigasi, Chuo-ku, Niigata 950-0075, Japan.
Ingrid J PickeringDepartment of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Chemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Graham N GeorgeDepartment of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Chemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address: g.george@usask.ca.
University of Saskatchewan · CASLAC National Accelerator Laboratory · USUniversity of Rochester · USEastman Chemical Company (United States) · USScripps Institution of Oceanography · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Mercury Vapor from Amalgam and Methylmercury Co-Exposure on NeurodevelopmentR01ES015578 · NIEHS · UNIVERSITY OF ROCHESTER · PI WATSON, GENE E · 2007 to 2011
$2.9M
NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R01 ES015578NIGMS NIH HHS P30 GM133894NIGMS NIH HHS P41 GM103393
6 · The paper itself

Abstract

The insidious and deadly nature of mercury's organometallic compounds is informed by two large scale poisonings due to industrial mercury pollution that occurred decades ago in Minamata and Niigata, Japan. The present study examined chemical speciation for both mercury and selenium in a historic umbilical cord sample from a child born to a mother who lived near the Agano River in Niigata. The mother had experienced mercury exposure leading to more than 50 ppm mercury measured in her hair and was symptomatic 9 years prior to the birth. We sought to determine the mercury and selenium speciation in the child's cord using Hg Lα1 and Se Kα1 high-energy resolution fluorescence detected X-ray absorption spectroscopy, the chemical speciation of mercury was found to be predominantly organometallic and coordinated to a thiolate. The selenium was found to be primarily in an organic form and at levels higher than those of mercury, with no evidence of mercury-selenium chemical species. Our results are consistent with mercury exposure at Niigata being due to exposure to organometallic mercury species.

Indexed as

MercuryMercury PoisoningMethylmercury CompoundsSeleniumChildEnvironmental ExposureFemaleHumansSynchrotronsMercuryMethylmercury CompoundsSeleniumHigh-energy resolution fluorescence detected X-ray absorption spectroscopyMercuryMinamataNeurotoxicologyNiigataSeleniumStem cellSynchrotron lightUmbilical cord

Identifiers

PMID38128735
PMCPMC11682714
OpenAlexW4389966096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.