Evidence map›Paper›PMID 38128481›Full record

ArticleCell systems2023

Modeling elucidates context dependence in adipose regulation.

Cameron D Vasquez, John G Albeck

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell systems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Cameron D VasquezDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
John G AlbeckDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA. Electronic address: jgalbeck@ucdavis.edu.
University of California, Davis · US

Funding

Postbaccalaureate Research Education Program at UC DavisR25GM116690 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOANNA Chungyen CHIU · 2017 to 2026
$3.7M
Control of gene expression by dynamic metabolic oscillationsR35GM139621 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALBECK, JOHN G. · 2021 to 2025
$1.9M
NIGMS NIH HHS R25 GM116690NIGMS NIH HHS R35 GM139621
6 · The paper itself

Abstract

Single-cell data and computational simulations reveal the dynamics of the transcription factors HIF1α and PPARγ during adipocyte differentiation and maturation. Modeling feedback within this network predicts a HIF1α-mediated choice between lipid accumulation and incomplete differentiation. In vitro experiments support this model, with implications for adipose dynamics in metabolic disorders involving hypoxia.

Indexed as

AdipocytesObesityCell DifferentiationDiet, High-FatHumansTranscription FactorsTranscription Factors

Identifiers

PMID38128481
OpenAlexW4389991711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.