Evidence map›Paper›PMID 38128008›Full record

Observational studyPloS one2023

Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design.

Torri D Metz, Rebecca G Clifton, Richard Gallagher, Rachel S Gross, Leora I Horwitz, Vanessa L Jacoby, Susanne P Martin-Herz, Myriam Peralta-Carcelen, Harrison T Reeder, Carmen J Beamon and 41 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05172011 (NIH RECOVER), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05172011 active not recruitingnot on this map

NIH RECOVER: A Multi-site Observational Study of Post-acute Sequalae of SARS-CoV-2 Infection in Children

TypeobservationalSponsorNYU Langone HealthRan2022 to 2027Enrolled15,028ConditionsSARS-CoV-2 Infection
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
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  4. Observational
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  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors at 20 institutions in 1 country.

Torri D MetzDepartment of Obstetrics and Gynecology, University of Utah Health Hospitals and Clinics, Salt Lake City, UT, United States of America.ORCID 0000-0002-8161-2353
Rebecca G CliftonBiostatistics Center, The George Washington University, Washington, DC, United States of America.
Richard GallagherDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, United States of America.ORCID 0000-0002-6612-3463
Rachel S GrossDepartment of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States of America.
Leora I HorwitzDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, United States of America.
Vanessa L JacobyDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States of America.
Susanne P Martin-HerzDepartment of Pediatrics, Division of Developmental Medicine, University of California, San Francisco, San Francisco, CA, United States of America.
Myriam Peralta-CarcelenDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Harrison T ReederDepartment of Biostatistics, Massachusetts General Hospital, Boston, MA, United States of America.
Carmen J BeamonDepartment of Maternal Fetal Medicine, WakeMed Health and Hospitals, Raleigh, NC, United States of America.
James ChanDepartment of Biostatistics, Massachusetts General Hospital, Boston, MA, United States of America.
A Ann ChangWomen's Health Research Clinical Center, University of California, San Francisco, San Francisco, CA, United States of America.
Maged M CostantineDepartment of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH, United States of America.
Megan L FitzgeraldDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, United States of America.
Andrea S FoulkesDepartment of Biostatistics, Massachusetts General Hospital, Boston, MA, United States of America.
Kelly S GibsonDepartment of Obstetrics and Gynecology, The MetroHealth System, Cleveland, OH, United States of America.
Nick GütheDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, United States of America.
Mounira HabliDivision Maternal Fetal Medicine, Trihealth Good Samaritan Hospital Maternal Fetal Medicine, Cincinnati, OH, United States of America.
David N HackneyDepartment of Obstetrics and Gynecology, University Hospitals Cleveland Medical Center: UH Cleveland Medical Center, Cleveland, OH, United States of America.
Matthew K HoffmanDepartment of Obstetrics and Gynecology, Christiana Care Health System, Newark, DE, United States of America.ORCID 0000-0002-2927-8693
M Camille HoffmanDepartment of Obstetrics & Gynecology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Brenna L HughesDepartment of Obstetrics and Gynecology, Duke University, Durham, NC, United States of America.
Stuart D KatzDepartment of Medicine, New York University School of Medicine, New York City, NY, United States of America.
Victoria LaleauDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, United States of America.
Gail MallettDepartment of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Hector Mendez-FigueroaDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Texas McGovern Medical School: The University of Texas Health Science Center at Houston John P. and Katherine G. McGovern Medical School, Houston, TX, United States of America.
Vanessa MonzonDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States of America.
Anna PalatnikDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, United States of America.
Kristy T S PalomaresDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Saint Peter's University Hospital, New Brunswick, NJ, United States of America.
Samuel ParryDepartment of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, United States of America.
Christian M PettkerDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, United States of America.
Beth A PlunkettDepartment of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, IL, United States of America.ORCID 0000-0003-1712-2226
Athena PoppasDivision of Cardiology, Brown University Warren Alpert Medical School, Providence, RI, United States of America.
Uma M ReddyDepartment of Obstetrics and Gynecology, Columbia University, New York City, NY, United States of America.
Dwight J RouseDepartment of Obstetrics and Gynecology, Brown University, Providence, RI, United States of America.
George R SaadeDepartment of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, United States of America.
Grecio J SandovalBiostatistics Center, The George Washington University, Rockville, MD, United States of America.ORCID 0000-0002-3601-6712
Shannon M SchlaterHuntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, United States of America.ORCID 0000-0003-3367-0281
Frank C SciurbaDepartment of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.
Hyagriv N SimhanDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.
Daniel W SkupskiDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, United States of America.ORCID 0000-0003-1504-0024
Amber SowlesDepartment of Obstetrics and Gynecology, University of Utah Health Hospitals and Clinics, Salt Lake City, UT, United States of America.
Tanayott ThaweethaiDepartment of Biostatistics, Massachusetts General Hospital, Boston, MA, United States of America.
Gelise L ThomasClinical and Translational Science Collaborative of Cleveland, Case Western Reserve University, Cleveland, OH, United States of America.
John M ThorpDepartment of Obstetrics and Gynecology, UNC: The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Alan T TitaDepartment of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Steven J WeinerBiostatistics Center, The George Washington University, Washington, DC, United States of America.
Samantha WeigandDepartment of Obstetrics and Gynecology, Wright State University Boonshoft School of Medicine, Dayton, OH, United States of America.
Lynn M YeeDepartment of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America.
Valerie J FlahermanDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, United States of America.
RECOVER Initiative
New York University · USUniversity of California, San Francisco · USMassachusetts General Hospital · USGeorge Washington University · USBrown University · USChristiana Care Health System · USNorthwestern University · USUniversity of Alabama at Birmingham · USUniversity of Pittsburgh · USUniversity of Utah Hospital · USCase Western Reserve University · USColumbia University · USCornell University · USDuke University · USGood Samaritan Hospital · USMedical College of Wisconsin · USMetroHealth · USNorthShore University HealthSystem · USSaint Peter's University Hospital · USThe Ohio State University Wexner Medical Center · US

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
Interactive Data Portals and Robust Analytic Tools to Wrap PASC Cohorts (iDRAW) OTA-21-015AOT2HL161841 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, KARLSON, ELIZABETH W · 2021 to 2024
$182.2M
NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS OT2 HL161841NHLBI NIH HHS OT2 HL161847
6 · The paper itself

Abstract

importancePregnancy induces unique physiologic changes to the immune response and hormonal changes leading to plausible differences in the risk of developing post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID. Exposure to SARS-CoV-2 during pregnancy may also have long-term ramifications for exposed offspring, and it is critical to evaluate the health outcomes of exposed children. The National Institutes of Health (NIH) Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC aims to evaluate the long-term sequelae of SARS-CoV-2 infection in various populations. RECOVER-Pregnancy was designed specifically to address long-term outcomes in maternal-child dyads.

methodsRECOVER-Pregnancy cohort is a combined prospective and retrospective cohort that proposes to enroll 2,300 individuals with a pregnancy during the COVID-19 pandemic and their offspring exposed and unexposed in utero, including single and multiple gestations. Enrollment will occur both in person at 27 sites through the Eunice Kennedy Shriver National Institutes of Health Maternal-Fetal Medicine Units Network and remotely through national recruitment by the study team at the University of California San Francisco (UCSF). Adults with and without SARS-CoV-2 infection during pregnancy are eligible for enrollment in the pregnancy cohort and will follow the protocol for RECOVER-Adult including validated screening tools, laboratory analyses and symptom questionnaires followed by more in-depth phenotyping of PASC on a subset of the overall cohort. Offspring exposed and unexposed in utero to SARS-CoV-2 maternal infection will undergo screening tests for neurodevelopment and other health outcomes at 12, 18, 24, 36 and 48 months of age. Blood specimens will be collected at 24 months of age for SARS-CoV-2 antibody testing, storage and anticipated later analyses proposed by RECOVER and other investigators. DISCUSSION: RECOVER-Pregnancy will address whether having SARS-CoV-2 during pregnancy modifies the risk factors, prevalence, and phenotype of PASC. The pregnancy cohort will also establish whether there are increased risks of adverse long-term outcomes among children exposed in utero. CLINICAL TRIALS.GOV IDENTIFIER: Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT05172011.

Indexed as

COVID-19AdultFemaleHumansPandemicsPost-Acute COVID-19 SyndromePregnancyProspective StudiesRetrospective StudiesSARS-CoV-2

Identifiers

PMID38128008
PMCPMC10734909
OpenAlexW4390046560

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.