ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Tolerant and Rapid Endochondral Bone Regeneration Using Framework-Enhanced 3D Biomineralized Matrix Hydrogels.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
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- An Injectable Magneto-Responsive Periosteum Reprograms Neutrophil Extracellular Trap Formation for Osteomyelitis Treatment.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Bioadhesive-Integrated 3D-Printed Multilayer Scaffolds Secure a Mechanically-Stable Osteoimmune Niche for Enhanced Bone Augmentation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Micro-Nano Composite System Combining Mesenchymal Stem Cells and Pirfenidone for Endometrial Regeneration via Microenvironment Remodeling.Advanced healthcare materials · 2026Article
- Quercetin-loaded PCL scaffold suppresses bone metastatic tumors and augments in situ bone formation.BMC biotechnology · 2026Article
- Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy.Advanced healthcare materials · 2026Review
- Engineering polyphenol-based osteogenic system for bone and cartilage repair: Transplantation, tissue engineering, and organoid.Journal of advanced research · 2026Review
- 3D-printed triboelectric scaffolds for fabricating BMSC-derived cartilage to repair bone defects and promote endochondral ossification.Bioactive materials · 2026Article
- Pathology-guided design of injectable hydrogels for precision therapy and cartilage regeneration in osteoarthritis.Regenerative biomaterials · 2026Review
- Programmable Macrophage Mimics for Inflammatory Meniscus Regeneration via Nanotherapy.Research (Washington, D.C.) · 2026Article
- Alleviation of tissue adhesion using dual-functional methacrylated gelatin via immunomodulation and antifibrotic activity.Frontiers in immunology · 2026Article
- Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration.Materials today. Bio · 2025Article
- Extraction of platelet-rich plasma retaining physiological-concentration erythrocytes and enriched leukocytes enhances its functional capabilities.Journal of orthopaedic surgery and research · 2025Article
- SUV39H1 facilitate the osteogenic differentiation of dental pulp stem cells by modulating lipid metabolism and mitochondrial dynamics through FASN via non-histone methylation and ubiquitination mechanism.Stem cell research & therapy · 2025Article
- Screening of molecular markers associated with hornless traits in Qira black sheep.BMC genomics · 2025Article
- From injury to integrity: tissue engineering solutions in combined bone repair and regeneration and muscle repair.Burns & trauma · 2025Review
- Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels.Frontiers in bioengineering and biotechnology · 2025Article
- Fabricating oxygen self-supplying 3D printed bioactive hydrogel scaffold for augmented vascularized bone regeneration.Bioactive materials · 2024Article
- Tolerant and Rapid Endochondral Bone Regeneration Using Framework-Enhanced 3D Biomineralized Matrix Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue-engineered bone has emerged as a promising alternative for bone defect repair due to the advantages of regenerative bone healing and physiological functional reconstruction. However, there is very limited breakthrough in achieving favorable bone regeneration due to the harsh osteogenic microenvironment after bone injury, especially the avascular and hypoxic conditions. Inspired by the bone developmental mode of endochondral ossification, a novel strategy is proposed for tolerant and rapid endochondral bone regeneration using framework-enhanced 3D biomineralized matrix hydrogels. First, it is meticulously designed 3D biomimetic hydrogels with both hypoxic and osteoinductive microenvironment, and then integrated 3D-printed polycaprolactone framework to improve their mechanical strength and structural fidelity. The inherent hypoxic 3D matrix microenvironment effectively activates bone marrow mesenchymal stem cells self-regulation for early-stage chondrogenesis via TGFβ/Smad signaling pathway due to the obstacle of aerobic respiration. Meanwhile, the strong biomineralized microenvironment, created by a hybrid formulation of native-constitute osteogenic inorganic salts, can synergistically regulate both bone mineralization and osteoclastic differentiation, and thus accelerate the late-stage bone maturation. Furthermore, both in vivo ectopic osteogenesis and in situ skull defect repair successfully verified the high efficiency and mechanical maintenance of endochondral bone regeneration mode, which offers a promising treatment for craniofacial bone defect repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.