Evidence map›Paper›PMID 38127985›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.

Ikki Sakuma, Rafael C Gaspar, Panu K Luukkonen, Mario Kahn, Dongyan Zhang, Xuchen Zhang, Sue Murray, Jaya Prakash Golla, Daniel F Vatner, Varman T Samuel and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  8. Severe Insulin Resistance Syndromes: Clinical Spectrum and Management.International journal of molecular sciences · 2025
    Review
  9. The Role of theInternational journal of molecular sciences · 2025
    Review
  10. Article
  11. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ikki SakumaDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Rafael C GasparDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Panu K LuukkonenDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0003-2085-679X
Mario KahnDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Dongyan ZhangDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0002-4036-3987
Xuchen ZhangDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520.
Sue MurrayIonis Pharmaceuticals, Carlsbad, CA.
Jaya Prakash GollaDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Daniel F VatnerDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0003-2073-0273
Varman T SamuelDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Kitt Falk PetersenDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0003-2664-670X
Gerald I ShulmanDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.ORCID 0000-0003-1529-5668
Yale University · USChiba University · JPHoward Hughes Medical Institute · USIonis Pharmaceuticals (United States) · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0M
Development of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human PrimatesR01DK119968 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2019 to 2024
$2.7M
Metabolic heterogeneity underlying hypertriglyceridemia in insulin resistanceR01DK124272 · NIDDK · YALE UNIVERSITY · PI VATNER, DANIEL · 2020 to 2024
$2.3M
Mechanism of Renal Cortical Insulin ResistanceR01DK133143 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2022 to 2025
$2.3M
Targeting hepatic mitochondrial oxidation to treat NAFLD, NASH and type 2 diabetesR01DK135645 · NIDDK · YALE UNIVERSITY · PI KITT F PETERSEN, GERALD I SHULMAN · 2024 to 2026
$2.1M
Exploring mitochondrialflux and lipid compartmentation in vivo to develop new therapies for alcoholic liver diseaseR21AA029457 · NIAAA · YALE UNIVERSITY · PI SAMUEL, VARMAN T · 2022 to 2023
$440k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R21 AA029457NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK119968NIDDK NIH HHS R01 DK124272NIDDK NIH HHS R01 DK133143NIDDK NIH HHS R01 DK135645
6 · The paper itself

Abstract

AGPAT2 (1-acyl-sn-glycerol-3-phosphate-acyltransferase-2) converts lysophosphatidic acid (LPA) into phosphatidic acid (PA), and mutations of the

Indexed as

Fatty LiverLipodystrophyOvernutrition1-Acylglycerol-3-Phosphate O-AcyltransferaseAcyltransferasesAdipose Tissue, WhiteAnimalsGlycerolInflammationLysophospholipidsMalePhosphatesPhosphatidic AcidsRatsRats, Sprague-Dawley1-Acylglycerol-3-Phosphate O-AcyltransferaseAcyltransferasesGlycerollysophosphatidic acidLysophospholipidsPhosphatesPhosphatidic AcidsAGPAT2congenital generalized lipodystrophyinflammationlysophosphatidic acidphosphatidic acid

Identifiers

PMID38127985
PMCPMC10756285
OpenAlexW4390046301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.