Evidence map›Paper›PMID 38127686›Full record

ReviewPLoS pathogens2023

Mechanisms of pathogenicity for the emerging fungus Candida auris.

Mark V Horton, Ashley M Holt, Jeniel E Nett

Open access · goldAbstract readReview
In one paragraph

Review in PLoS pathogens, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Methods for skin load reduction of Candida auris: a systematic review.Antimicrobial resistance and infection control · 2026
    Pooled it
  2. Article
  3. Journal of fungi (Basel, Switzerland) · 2026
    Review
  4. Active Screening forJournal of fungi (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Early Signal Without Clinical Cases: A Single Clade IIIJournal of fungi (Basel, Switzerland) · 2026
    Article
  10. Review
  11. Microbiology spectrum · 2026
    Article
  12. Review
  13. UnderstandingJournal of medical microbiology · 2026
    Review
  14. Outcomes of patients withAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026
    Article
  15. Infection and drug resistance · 2026
    Article
  16. Article
  17. First report ofMedical mycology case reports · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mark V HortonDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
Ashley M HoltDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
Jeniel E NettDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.ORCID 0000-0001-8587-6244
University of Wisconsin–Madison · US

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Mechanism(s) of pathogenicity for Candida aurisR01AI145939 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2020 to 2025
$2.7M
Characterizing Candida auris skin colonization and high-burden biofilm formationR21AI159583 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI NETT, JENIEL E · 2021 to 2022
$427k
NIAID NIH HHS R01 AI145939NIAID NIH HHS R21 AI159583NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

Candida auris recently emerged as an urgent public health threat, causing outbreaks of invasive infections in healthcare settings throughout the world. This fungal pathogen persists on the skin of patients and on abiotic surfaces despite antiseptic and decolonization attempts. The heightened capacity for skin colonization and environmental persistence promotes rapid nosocomial spread. Following skin colonization, C. auris can gain entrance to the bloodstream and deeper tissues, often through a wound or an inserted medical device, such as a catheter. C. auris possesses a variety of virulence traits, including the capacity for biofilm formation, production of adhesins and proteases, and evasion of innate immune responses. In this review, we highlight the interactions of C. auris with the host, emphasizing the intersection of laboratory studies and clinical observations.

Indexed as

CandidaCandidiasisAntifungal AgentsCandida aurisDisease OutbreaksHumansVirulenceAntifungal Agents

Identifiers

PMID38127686
PMCPMC10735027
OpenAlexW4390062177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.