Evidence map›Paper›PMID 38127662›Full record

ArticleJournal of integrative bioinformatics2023

Gene-network based analysis of human placental trophoblast subtypes identifies critical genes as potential targets of therapeutic drugs.

Andreas Ian Lackner, Jürgen Pollheimer, Paulina Latos, Martin Knöfler, Sandra Haider

Open access · diamondAbstract read
In one paragraph

Article in Journal of integrative bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andreas Ian LacknerDepartment of Obstetrics and Gynecology, Maternal-Fetal Immunology Group, Medical University of Vienna, Vienna, Austria.
Jürgen PollheimerDepartment of Obstetrics and Gynecology, Maternal-Fetal Immunology Group, Medical University of Vienna, Vienna, Austria.
Paulina LatosCenter for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.
Martin KnöflerDepartment of Obstetrics and Gynecology, Reproductive Biology Unit, Medical University of Vienna, Vienna, Austria.
Sandra HaiderDepartment of Obstetrics and Gynecology, Reproductive Biology Unit, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-2409-1317
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During early pregnancy, extravillous trophoblasts (EVTs) play a crucial role in modifying the maternal uterine environment. Failures in EVT lineage formation and differentiation can lead to pregnancy complications such as preeclampsia, fetal growth restriction, and pregnancy loss. Despite recent advances, our knowledge on molecular and external factors that control and affect EVT development remains incomplete. Using trophoblast organoid

Indexed as

Gene Regulatory NetworksPlacentaFemaleHumansPlacentationPregnancyTransforming Growth Factor betaTrophoblastsTransforming Growth Factor betadrug-gene interactionplacental developmentWGCNA

Identifiers

PMID38127662
PMCPMC10777358
OpenAlexW4390047733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.