ArticleeLife2023
Apoptosis recognition receptors regulate skin tissue repair in mice.
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Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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0cells of the map it votes in
38citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
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Who cites it
38 citing papers in PubMed, 39 citations in OpenAlex.
- Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Macrophage-Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing.Communications biology · 2026Review
- Kill two birds with one stone: Reprogramming tumor microenvironment with growth differentiation factor 11.World journal of gastroenterology · 2026Article
- Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance.Cell communication and signaling : CCS · 2026Review
- Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish.bioRxiv : the preprint server for biology · 2026Article
- Total Saponins from Rhizoma Panacis Majoris Promote Wound Healing in Diabetic Rats by Regulating Inflammatory Dysregulation.International journal of molecular sciences · 2026Article
- 4D multimodal wound healing atlas reveals organ-level controls of repair phase transitions.bioRxiv : the preprint server for biology · 2026Article
- TAK1 activates PANoptosis through the NF-κB signalling pathway to delay diabetic wound healing.Burns & trauma · 2026Article
- Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential.Frontiers in clinical diabetes and healthcare · 2026Review
- Tuoli Tounong decoction promotes lesion resolution in granulomatous lobular mastitis by remodeling a Caspase-8-associated PANoptosis-like cell death network.Frontiers in immunology · 2026Article
- Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration.Bioactive materials · 2025Review
- Yeast culture in weaned lamb feed: a proteomic journey into enhanced rumen health and growth.Journal of animal science and biotechnology · 2025Article
- Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair.Seminars in respiratory and critical care medicine · 2025Review
- Single-Cell RNA-Seq Reveals Aging-Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury.Aging cell · 2025Article
- Growth arrest specific-6 and angiotoxin receptor-like signaling drive oral regenerative wound repair.Science translational medicine · 2025Article
- Impaired efferocytosis by monocytes and monocyte-derived macrophages in patients with poorly controlled type 2 diabetes.World journal of diabetes · 2025Article
- Proinflammatory cytokines sensitise mesenchymal stromal cells to apoptosis.Cell death discovery · 2025Article
- Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice.World journal of diabetes · 2025Article
- Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis.Cell communication and signaling : CCS · 2025Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Olivia JustynskiDept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0002-0774-5983
Kate BridgesDept. of Biomedical Engineering, Yale University, New Haven, United States.ORCID 0000-0003-3642-7068
Will KrauseDept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0001-7585-5749
Maria Fernanda ForniDept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0002-3335-9023
Quan M PhanWashington State University, SMB, Pullman, United States.
Teresa Sandoval-SchaeferDept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.
Kristyn CarterDept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.
Diane E KingSunnycrest Bioinformatics, Flemington, United States.
Henry C HsiaDept. of Surgery (Plastic), Yale School of Medicine, New Haven, United States.
Michael I GazesDept of Podiatric Surgery, Yale New Haven Hospital, New Haven, United States.
Steven D VyceDept of Podiatric Surgery, Yale New Haven Hospital, New Haven, United States.
Ryan R DriskellWashington State University, SMB, Pullman, United States.ORCID 0000-0001-7673-2564
Kathryn Miller-JensenDept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0002-7233-0100
Valerie HorsleyDept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0002-1254-5839
Yale University · USWashington State University · USYale New Haven Hospital · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MSkill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0MUPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1MSystems analysis of cell-cell communication networks and immune activity in the melanoma tumor microenvironmentU01CA238728 · NCI · YALE UNIVERSITY · PI BOSENBERG, MARCUS W, MILLER-JENSEN, KATHRYN · 2020 to 2024
$2.9MSystems analysis of cell-to-cell variability and signaling-transcription factor motifs regulating macrophage responses to conflicting environmental cuesR01GM123011 · NIGMS · YALE UNIVERSITY · PI MILLER-JENSEN, KATHRYN · 2017 to 2025
$2.5MDefining the role of lymphatic vessels in wound healingR01AR079232 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2021 to 2025
$2.5MMechanism and Impact of Dermal adipocyte remodeling in skin fibrosisR01AR076938 · NIAMS · YALE UNIVERSITY · PI ATIT, RADHIKA P, HORSLEY, VALERIE · 2020 to 2024
$2.4MAdipocyte lipolysis regulates skin repairR01AR075412 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2019 to 2023
$2.3MNCATS NIH HHS UL1 TR001863NCI NIH HHS U01 CA238728NIAMS NIH HHS R01 AR075412NIAMS NIH HHS R01 AR076938NIAMS NIH HHS R01 AR079232NIGMS NIH HHS K12 GM106996NIGMS NIH HHS R01 GM123011NIGMS NIH HHS T32 GM007223NIH HHS Predoctoral Training Program in Cellular and Molecular BiologyNIH HHS R01-CA238728NIH HHS R01-GM123011NIH HHS T32 T32GM007223NIH HHS U01-CA238728
Abstract
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition and clearance of apoptotic cells regulate repair are not fully understood. Here, we use single-cell RNA sequencing to provide a map of the cellular dynamics during early inflammation in mouse skin wounds. We find that apoptotic pathways and efferocytosis receptors are elevated in fibroblasts and immune cells, including resident Lyve1
Indexed as
ApoptosisEfferocytosisAnimalsFibroblastsHumansInflammationInhibition, PsychologicalMiceapoptosiscell biologyefferocytosishumanimmunologyinflammationmouserepairskinwound healing
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.