Evidence map›Paper›PMID 38127206›Full record

ArticleEuropean geriatric medicine2024

Diabetes mellitus increases risk of adverse drug reactions and death in hospitalised older people: the SENATOR trial.

Anagha Chinmayee, Selvarani Subbarayan, Phyo Kyaw Myint, Antonio Cherubini, Alfonso J Cruz-Jentoft, Mirko Petrovic, Adalsteinn Gudmundsson, Stephen Byrne, Denis O'Mahony, Roy L Soiza

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European geriatric medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 6 countries.

Anagha ChinmayeeAgeing Clinical and Experimental Research (ACER) Group, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Selvarani SubbarayanAgeing Clinical and Experimental Research (ACER) Group, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Phyo Kyaw MyintAgeing Clinical and Experimental Research (ACER) Group, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
Antonio CherubiniGeriatria, Accettazione Geriatrica e Centro Di Ricerca Per L'invecchiamento, IRCCS INRCA, Ancona, Italy.
Alfonso J Cruz-JentoftServicio de Geriatría, Hospital Universitario Ramón y Cajal (IRICYS), Madrid, Spain.
Mirko PetrovicDepartment of Geriatrics, Ghent University Hospital, Ghent, Belgium.
Adalsteinn GudmundssonLandspitali University Hospital, Reykjavik, Iceland.
Stephen ByrneSchool of Pharmacy, University College Cork, Cork, Ireland.
Denis O'MahonyDepartment of Medicine (Geriatrics), School of Medicine, University College Cork, Cork, Ireland.
Roy L SoizaAgeing Clinical and Experimental Research (ACER) Group, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK. roy.soiza@nhs.scot.ORCID 0000-0002-1397-4272
University of Aberdeen · GBUniversity College Cork · IEGhent University Hospital · BEHospital Universitario Ramón y Cajal · ESIstituti di Ricovero e Cura a Carattere Scientifico · ITReykjavík University · IS

Funding

FP7 Health FP7/2007-2013 grant number 305930
6 · The paper itself

Abstract

purposeAdverse drug reactions (ADRs) are a major cause of morbidity and mortality, especially in older people. Older people with diabetes mellitus may be at especially high risk of ADRs but this risk has not been well studied. This study aimed to compare severity and type of ADRs in hospitalised, multimorbid older people with and without diabetes and secondly to assess the impact of ADRs on mortality, rehospitalisation and length of stay.

methodsParticipants in the SENATOR (Software Engine for the Assessment and optimization of drug and non-drug Therapy in Older peRsons) trial were assessed for 12 common and 'other' prevalent and incident adverse drug reactions using a blinded end-point adjudication process. Descriptive analyses, logistic regression and mediation analyses were undertaken.

resultsOf 1537 people in the SENATOR trial, 540 (35.1%) had diabetes mellitus (mean age 77.4 ± 7.3 years, 58.5% male). In the total population, 773 prevalent and 828 incident ADRs were reported. Both prevalent and incident symptomatic hypoglycaemia and incident acute kidney injury (AKI) were significantly more common in people with diabetes (p < 0.05). Patients with diabetes had higher all-cause mortality at 12 weeks than those without (9.1% vs 6.3%, p = 0.04). Mediation analysis revealed that mortality was significantly higher (OR = 1.43, Sobel test p = 0.048) in people with diabetes and ADRs causing AKI.

conclusionsOlder multimorbid people with diabetes presenting to hospital with acute illness have significantly more ADRs than those without, and a significantly higher mortality that is mediated by medication-associated AKI and poorer renal function.

Indexed as

Acute Kidney InjuryDiabetes MellitusDrug-Related Side Effects and Adverse ReactionsHypoglycemiaAgedAged, 80 and overFemaleHumansMaleMultimorbidityAdverse drug reactionsDiabetes mellitusMultimorbidityOlder peoplePolypharmacy

Identifiers

PMID38127206
PMCPMC10876722
OpenAlexW4390061274

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.