Evidence map›Paper›PMID 38127071›Full record

ArticleEuropean radiology2024

[

Minglei Yang, Xiaoxiao Li, Chuang Cai, Chunli Liu, Minjie Ma, Wendong Qu, Sheng Zhong, Enkuo Zheng, Huangkai Zhu, Feng Jin and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Minglei Yang *Department of Thoracic Surgery, Ningbo No. 2 Hospital, Ningbo, China.
Xiaoxiao Li *Shanghai Universal Cloud Medical Imaging Diagnostic Center, Shanghai, China.
Chuang Cai *School of Computer Science and Communication Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Chunli LiuShanghai Universal Cloud Medical Imaging Diagnostic Center, Shanghai, China.
Minjie MaDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Wendong QuDepartment of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China. quwendonga@126.com.
Sheng ZhongTailai Inc, Shanghai, China.
Enkuo ZhengDepartment of Thoracic Surgery, Ningbo No. 2 Hospital, Ningbo, China.
Huangkai ZhuDepartment of Thoracic Surgery, Ningbo No. 2 Hospital, Ningbo, China.
Feng JinShandong Key Laboratory of Infectious Respiratory Diseases, Shandong Public Health Clinical Center, Shandong University, Shandong, China. jf13791123070@163.com.
Huazheng ShiShanghai Universal Cloud Medical Imaging Diagnostic Center, Shanghai, China. 1090830052@qq.com.ORCID http://orcid.org/0009-0003-0647-2930
Ningbo No. 2 Hospital · CNShanghai Medical Information Center · CNFirst Hospital of Lanzhou University · CNJiangsu University · CNShandong University · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to develop and validate a radiomics model based on MATERIALS AND

methodsOne hundred eighty-five patients receiving neoadjuvant chemoimmunotherapy for NSCLC at 5 centers from January 2019 to December 2022 were included and divided into a training cohort and a validation cohort. Radiomics models were constructed via the least absolute shrinkage and selection operator (LASSO) method. The performances of models were evaluated by the area under the receiver operating characteristic curve (AUC). In addition, genetic analyses were conducted to reveal the underlying biological basis of the radiomics score.

resultsAfter the LASSO process, 9 PET-CT radiomics features were selected for pCR prediction. In the validation cohort, the ability of PET-CT radiomics model to predict pCR was shown to have an AUC of 0.818 (95% confidence interval [CI], 0.711, 0.925), which was better than the PET radiomics model (0.728 [95% CI, 0.610, 0.846]), CT radiomics model (0.732 [95% CI, 0.607, 0.857]), and maximum standard uptake value (0.603 [95% CI, 0.473, 0.733]) (p < 0.05). Moreover, a high radiomics score was related to the upregulation of pathways suppressing tumor proliferation and the infiltration of antitumor immune cell.

conclusionThe proposed PET-CT radiomics model was capable of predicting pCR to neoadjuvant chemoimmunotherapy in NSCLC patients. CLINICAL RELEVANCE STATEMENT: This study indicated that the generated KEY POINTS: • Recognizing patients potentially benefiting neoadjuvant chemoimmunotherapy is critical for individualized therapy of lung cancer. • [

Indexed as

Carcinoma, Non-Small-Cell LungFluorodeoxyglucose F18Lung NeoplasmsNeoadjuvant TherapyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsAgedFemaleHumansImmunotherapyMaleMiddle AgedPredictive Value of TestsRadiomicsRetrospective StudiesTreatment OutcomeFluorodeoxyglucose F18RadiopharmaceuticalsChemoimmunotherapyNon-small cell lung cancerPathological responsePET-CTRadiomics

Identifiers

PMID38127071
OpenAlexW4390055281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.