Evidence map›Paper›PMID 38127070›Full record

ArticleeLife2023

The lncRNA

Benjamin D Wheeler, John D Gagnon, Wandi S Zhu, Priscila Muñoz-Sandoval, Simon K Wong, Dimitre S Simeonov, Zhongmei Li, Rachel DeBarge, Matthew H Spitzer, Alexander Marson and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Genes & development · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. FOSL1-mediated LINC01566 negatively regulates CD4Journal of neuroinflammation · 2024
    Article
  14. Article
  15. Article
  16. The lncRNAeLife · 2023
    Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Benjamin D WheelerDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.ORCID 0000-0001-5310-7213
John D GagnonDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.ORCID 0000-0001-6208-5781
Wandi S ZhuDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.
Priscila Muñoz-SandovalDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.
Simon K WongDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.
Dimitre S SimeonovDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.
Zhongmei LiGladstone-UCSF Institute of Genomic Immunology, San Francisco, United States.
Rachel DeBargeDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.ORCID 0000-0001-9223-1364
Matthew H SpitzerDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.
Alexander MarsonDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.
K Mark AnselDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, United States.ORCID 0000-0003-4840-9879
University of California, San Francisco · USGladstone Institutes · US

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Role of miRNAs in Th2-Driven inflammation in AsthmaR01HL109102 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Karl Mark Ansel · 2011 to 2026
$5.5M
Howard Hughes Medical Institute Gilliam FellowshipNHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL109102NIAID NIH HHS T32 AI007334NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers. Through biochemical analysis of RNA:protein interactions, we uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA

Indexed as

Memory T CellsMicroRNAsRNA, Long NoncodingT-Lymphocytes, CytotoxicAnimalsCD28 AntigensMiceCD28 AntigensMalat1 long non-coding RNA, mouseMicroRNAsMirn15 microRNA, mouseMirn16 microRNA, mouseRNA, Long NoncodinghumanimmunologyinflammationLCMVListerialong non-coding RNAmicroRNAmiRNAmousespongeviruses

Identifiers

PMID38127070
PMCPMC10735224
OpenAlexW4384931055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.