Evidence map›Paper›PMID 38126782›Full record

ArticlemBio2024

Development and implementation of a Type I-C CRISPR-based programmable repression system for

Wendy E Geslewitz, Amaris Cardenas, Xufei Zhou, Yan Zhang, Alison K Criss, H Steven Seifert

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. CRISPRi-mediated repression of threeJournal of bacteriology · 2025
    Article
  5. Review
  6. Expanding the genetic toolbox forApplied and environmental microbiology · 2024
    Article
  7. mBio · 2024
    Article
  8. bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wendy E GeslewitzDepartment of Microbiology and Immunology, Northwestern University, Chicago, Illinois, USA.
Amaris CardenasDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Xufei ZhouDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Yan ZhangDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Alison K CrissDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0001-7738-3757
H Steven SeifertDepartment of Microbiology and Immunology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-8651-0375

Funding

Mechanisms of Gonococcal Pilin Antigenic/Phase VariationR37AI033493 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hank S. SEIFERT · 2003 to 2026
$10.1M
Survival of Neisseria gonorrhoeae after primary human neutrophil challengeR01AI097312 · NIAID · UNIVERSITY OF VIRGINIA · PI CRISS, ALISON K · 2012 to 2022
$4.6M
Targeting the functions of the gonococcal Type lV pilusR01AI146073 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hank S. SEIFERT · 2020 to 2026
$3.3M
Generation of DNA memory by bacterial CRISPR-Cas9 systemsR35GM137883 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yan Zhang · 2020 to 2026
$3.0M
Ordered gene knockout libraries for Neisseria gonorrhoeaeR24AI155395 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SEIFERT, HANK S. · 2021 to 2023
$2.2M
Survival of Neisseria gonorrhoeae after primary human neutrophil challengeR37AI097312 · NIAID · UNIVERSITY OF VIRGINIA · PI Alison K Criss · 2025 to 2026
$1.1M
Investigating the role of lipooligosaccharide sialylation in Neisseria gonorrhoeae-neutrophil interactionsF31AI157528 · NIAID · UNIVERSITY OF VIRGINIA · PI CARDENAS, AMARIS J. · 2021 to 2023
$71k
NIAID NIH HHS F31 AI157528NIAID NIH HHS R01 AI097312NIAID NIH HHS R01 AI146073NIAID NIH HHS R24 AI155395NIAID NIH HHS R37 AI033493NIAID NIH HHS R37 AI097312NIGMS NIH HHS R35 GM137883
6 · The paper itself

Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR) are prokaryotic adaptive immune systems regularly utilized as DNA-editing tools. While

Indexed as

CRISPR-Cas SystemsGonorrheaDNAHumansIsopropyl ThiogalactosideNeisseria gonorrhoeaeDNAIsopropyl ThiogalactosideCRISPRessential genesNeisseria gonorrhoeaeneutrophilsOpapilitranscriptional regulation

Identifiers

PMID38126782
PMCPMC10865793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.