Evidence map›Paper›PMID 38126750›Full record

ArticleApplied and environmental microbiology2024

Penicillin-binding protein redundancy in

Stephanie L Mitchell, Daniel B Kearns, Erin E Carlson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Stephanie L MitchellDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.
Daniel B KearnsDepartment of Biology, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0002-3460-8378
Erin E CarlsonDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-8287-8893

Funding

Swarming motility and the regulation of flagellar biosynthesis in Bacillus subtilisR35GM131783 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Daniel B Kearns · 2019 to 2026
$3.9M
Chemical Methods to Characterize Penicillin-Binding Protein Function and InteractionsR01GM140486 · NIGMS · UNIVERSITY OF MINNESOTA · PI CARLSON, ERIN ELIZABETH · 2020 to 2023
$1.2M
NIGMS NIH HHS R01 GM140486NIGMS NIH HHS R35 GM131783
6 · The paper itself

Abstract

Penicillin-binding proteins (PBPs) play critical roles in cell wall construction, cell shape maintenance, and bacterial replication. Bacteria maintain a diversity of PBPs, indicating that despite their apparent functional redundancy, there is differentiation across the PBP family. Apparently-redundant proteins can be important for enabling an organism to cope with environmental stressors. In this study, we evaluated the consequence of environmental pH on PBP enzymatic activity in

Indexed as

Bacillus subtilisBacterial ProteinsCell WallCytoplasmPenicillin-Binding ProteinsBacterial ProteinsPenicillin-Binding Proteinsactivity-based probesBacilluscell divisionpenicillin-binding proteinspH regulation

Identifiers

PMID38126750
PMCPMC10807460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.