Evidence map›Paper›PMID 38126466›Full record

ArticleRevista espanola de salud publica2023

[COVID-19 vaccination at the University of Alicante (Spain): detection of neutralizing antibodies against SARS-CoV-2 by rapid serological test, a cross-sectional study].

Ana C Montagud, Nancy Vicente-Alcalde, Eva M Gabaldón-Bravo, José Antonio Hurtado-Sánchez, Emilia Montagud, Cecilia M Egoavil, Enrique Chavarría-Alarcón, Pablo Caballero, José Tuells

Open access · greenAbstract readEnglish Abstract
In one paragraph

Article in Revista espanola de salud publica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ana C MontagudServicio de Inmunología; Plataforma oncológica; Hospital Quirónsalud Torrevieja. Alicante. España.
Nancy Vicente-AlcaldeDepartamento de Enfermería y Fisioterapia; Facultad de Ciencias de la Salud; Universidad CEU-Cardenal Herrera. Elche. España.
Eva M Gabaldón-BravoDepartamento de Enfermería; Facultad de Ciencias de la Salud; Universidad de Alicante. Alicante. España.
José Antonio Hurtado-SánchezDepartamento de Enfermería; Facultad de Ciencias de la Salud; Universidad de Alicante. Alicante. España.
Emilia MontagudServicio de Farmacia de Atención Primaria; Departamento de Salud de Torrevieja. Alicante. España.
Cecilia M EgoavilHospital General Universitario de Alicante; Unidad de Farmacología Clínica. Alicante. España.
Enrique Chavarría-AlarcónCátedra Balmis de Vacunología UA-ASISA; Universidad de Alicante. Alicante. España.
Pablo CaballeroDepartamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e historia de la ciencia; Universidad de Alicante. Alicante. España.
José TuellsInstituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL). Alicante. España.
University of Alicante · ESHospital Quirón Torrevieja · ESUniversidad Cardenal Herrera CEU · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNeutralizing antibodies against SARS-CoV-2 have shown to be an effective tool for the analysis of the immunity generated against COVID-19. Numerous seroprevalence studies carried out in different groups have made it possible to draw a global map of vaccination coverage through the use of rapid lateral flow immunochromatography serological tests for clinical and epidemiological purposes. The objective of our study was to determine the degree of immunity against SARS-CoV-2 associated with the presence of neutralizing antibodies in administrative staff, teachers and students at the University of Alicante by means of a rapid serological test and to learn about their experience with vaccination against COVID-19.

methodsA cross-sectional epidemiological study was designed, based on the prevalence of antibodies against the S protein (spike) of SARS-CoV-2. A total of 888 people participated. The study was carried out with a single test (July 6 to July 22, 2021). Using logistic regression, adjusted Odds Ratios were calculated according to sex, age, type of vaccine, number of vaccine doses received, complete vaccination schedule, and having had COVID-19.

resultsThe vaccines received mostly were Vaxzevria® and Comirnaty®, with 73.3% between both, although 67.2% presented a complete regimen. The results of the OJABIO rapid neutralizing antibody test gave a positive result in 61.4% of the sample. There was a high association between the variables COVID-19 infection, two doses of vaccine, Spikevax® or Comirnaty® vaccine, and eighteen/twenty-nine years old group with a positive result on the OJABIO test. A total of 712 subjects answered the parallel survey (80%) on adverse effects and preferences between the different vaccines against COVID-19.

conclusionsThe vaccination status against COVID-19 in the university community after six months of the start of national immunization strategies reflects low coverage despite the excellent willingness to get vaccinated. Neutralizing antibodies (NAb) rapid tests can be useful to guide immunization strategies and decide when to administer new booster doses.

Indexed as

COVID-19SARS-CoV-2Antibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19 TestingCOVID-19 VaccinesCross-Sectional StudiesHumansSeroepidemiologic StudiesSerologic TestsSpainVaccinationAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesCOVID-19Lateral flow assayLateral flow immunochromatographyNeutralizing antibodiesSARS-CoV-2Serological testSpain

Identifiers

PMID38126466
PMCPMC11571752
OpenAlexW4390067544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.