Evidence map›Paper›PMID 38126226›Full record

ArticleCirculation. Heart failure2024

Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size.

Vineet Agrawal, Ali Manouchehri, Nataraja S Vaitinadin, Mingjian Shi, Minoo Bagheri, Deepak K Gupta, Iftikhar J Kullo, Yuan Luo, Elizabeth M McNally, Megan J Puckelwartz and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Vineet Agrawal *Vanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (V.A., A.M., M.B., D.K.G., J.F.F., Q.S.W.).ORCID 0000-0002-8457-6722
Ali Manouchehri *Vanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (V.A., A.M., M.B., D.K.G., J.F.F., Q.S.W.).
Nataraja S VaitinadinDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (N.S.V., J.D.M.).
Mingjian ShiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN (M.S., J.D.M.).ORCID 0000-0003-1569-9822
Minoo BagheriVanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (V.A., A.M., M.B., D.K.G., J.F.F., Q.S.W.).ORCID 0000-0002-6093-613X
Deepak K GuptaVanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (V.A., A.M., M.B., D.K.G., J.F.F., Q.S.W.).ORCID 0000-0003-2191-3485
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN (I.J.K.).ORCID 0000-0002-6524-3471
Yuan LuoDepartment of Preventive Medicine (Y.L.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0003-0195-7456
Elizabeth M McNallyCenter for Genetic Medicine (E.M.M., M.J.P.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-1221-719X
Megan J PuckelwartzCenter for Genetic Medicine (E.M.M., M.J.P.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-0455-2983
Jane F FergusonVanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (V.A., A.M., M.B., D.K.G., J.F.F., Q.S.W.).ORCID 0000-0001-6896-1025
Quinn S Wells *Vanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (V.A., A.M., M.B., D.K.G., J.F.F., Q.S.W.).ORCID 0000-0003-3899-0313
Jonathan D Mosley *Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (N.S.V., J.D.M.).ORCID 0000-0001-6421-2887
Vanderbilt University Medical Center · USNorthwestern University · USDepartment of Veterans Affairs · AUMayo Clinic · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Pharmacogenomics of Arrhythmia TherapyU19HL065962 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RODEN, DAN M · 2010 to 2014
$17.4M
Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Variation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0M
DNA Sequencing Support for the eMERGE NetworkU01HG008664 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2015 to 2019
$10.9M
American Heart Association-American Stroke Association 16FTF30130005BLRD VA IK2 BX005828NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS T32 HG008341NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG006385NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008664NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01 HG008673NHGRI NIH HHS U01 HG008676NHGRI NIH HHS U01 HG008679NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008684NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01 HG008701NHLBI NIH HHS K01 HL165020NHLBI NIH HHS K08 HL153956NHLBI NIH HHS K24 HL137010NHLBI NIH HHS R01 HL128075NHLBI NIH HHS R01 HL142856NHLBI NIH HHS T32 HL007411NHLBI NIH HHS U19 HL065962NICHD NIH HHS R01 HD074711NIGMS NIH HHS P50 GM115305NIGMS NIH HHS R01 GM130791NIGMS NIH HHS RC2 GM092618NINDS NIH HHS R01 NS032830
6 · The paper itself

Abstract

backgroundGreater left atrial size is associated with a higher incidence of cardiovascular disease and mortality, but the full spectrum of diagnoses associated with left atrial enlargement in sex-stratified clinical populations is not well known. Our study sought to identify genetic risk mechanisms affecting left atrial diameter (LAD) in a clinical cohort.

methodsUsing Vanderbilt deidentified electronic health record, we studied 6163 females and 5993 males of European ancestry who had at least 1 LAD measure and available genotyping. A sex-stratified polygenic score was constructed for LAD variation and tested for association against 1680

resultsA phenome-wide association study identified 25

conclusionsIn a clinical population, we identified, by genomic approaches, potential etiologic risk factors for larger LAD. Further studies are needed to confirm the extent to which these risk factors may be modified to prevent or reverse adverse left atrial remodeling and the extent to which sex modifies these risk factors.

Indexed as

Atrial FibrillationCoronary Artery DiseaseHeart Failure, SystolicFemaleGenomicsHeart AtriaHumansMaleMendelian Randomization AnalysisRisk Factorsatrial fibrillationbody mass indexcoronary artery diseasegenotypeMendelian randomization analysis

Identifiers

PMID38126226
PMCPMC10842187
OpenAlexW4390058819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.